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Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

DOI :

10.3791/54995-v

July 23rd, 2017

July 23rd, 2017

9,708 Views

1Department of Biomedical Engineering, Peking University, 2Institute of Molecular Medicine, Peking University

This protocol demonstrates murine islet isolation and seeding onto a decellularized scaffold. Scaffold-supported islets were transplanted into the epididymal fat pad of streptozotocin (STZ)-induced diabetic mice. Islets survived at the transplantation site and reversed the hyperglycemic condition.

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