February 11th, 2019
•A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.
Tags
Related Videos
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
Labeling of Single Cells in the Central Nervous System of Drosophila melanogaster
An Injury Paradigm to Investigate Central Nervous System Repair in Drosophila
Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation
In vivo Optogenetic Stimulation of the Rodent Central Nervous System
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
Quantitative Cell Biology of Neurodegeneration in Drosophila Through Unbiased Analysis of Fluorescently Tagged Proteins Using ImageJ
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved