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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

DOI :

10.3791/60274-v

October 29th, 2019

October 29th, 2019

16,896 Views

1Biogen, Inc., 2Ionis Pharmaceuticals

Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.

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