October 29th, 2019
•Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.
Related Videos
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
Production of Lentiviral Vectors for Transducing Cells from the Central Nervous System
Labeling of Single Cells in the Central Nervous System of Drosophila melanogaster
An Injury Paradigm to Investigate Central Nervous System Repair in Drosophila
Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections
In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation
In vivo Optogenetic Stimulation of the Rodent Central Nervous System
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved