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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

DOI :

10.3791/1992-v

11:51 min

August 16th, 2010

August 16th, 2010

29,672 Views

1Department of Neurological Surgery, University of California, San Francisco - UCSF

Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.

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Systemic Drug Delivery

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