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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

DOI :

10.3791/50326-v

14:55 min

May 12th, 2013

May 12th, 2013

58,407 Views

1Department of Neurology, Washington University in St. Louis School of Medicine

We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to rats.

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Direct Intraventricular Delivery

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