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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

DOI :

10.3791/57242-v

April 4th, 2018

April 4th, 2018

13,464 Views

1Department of Micro Engineering, Kyoto University, 2Graduate School of Medical Sciences, Kyushu University, 3International Research Center for Medical Sciences (IRCMS), Kumamoto University

The protocol describes how to engineer a perfusable vascular network in a spheroid. The spheroid's surrounding microenvironment is devised to induce angiogenesis and connect the spheroid to the microchannels in a microfluidic device. The method allows the perfusion of the spheroid, which is a long-awaited technique in three-dimensional cultures.

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Perfusable Vascular Network

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