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A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

DOI :

10.3791/57397-v

April 5th, 2018

April 5th, 2018

18,037 Views

1Department of Anaesthesiology, University Hospital Bonn, 2Department of Cardiac Surgery, University Hospital Bonn, 3Institute of Physiology 2, University of Bonn, 4Department of Medicine - Cardiology, University Hospital Bonn

Here, we present a protocol of Transverse Aortic constriction (TAC) via a lateral thoracotomy. This technique is a minimally invasive, closed chest surgical procedure aiming to simulate pressure overload and heart failure in mice utilizing standard TAC laboratory settings.

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Transverse Aortic Constriction

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