Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

9.7K Views

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06:40 min

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May 22nd, 2018

DOI :

10.3791/57617-v

May 22nd, 2018

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Christiane Jungen¹^,², Katharina Scherschel¹^,², Nadja I. Bork²^,³, Pawel Kuklik¹, Christian Eickholt¹, Helge Kniep¹, Niklas Klatt¹^,², Stephan Willems¹^,², Viacheslav O. Nikolaev²^,³, Christian Meyer¹^,²

¹Department of Cardiology-Electrophysiology, cNEP (cardiac Neuro- and Electrophysiology research group), University Heart Center, University Hospital Hamburg-Eppendorf, ²DZHK (German Center for Cardiovascular Research), ³Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf

Summary

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Keywords Intracardiac Neurons

Cardiac Electrophysiology

Arrhythmogenesis

Langendorff System

Autonomic Nervous System

CAMP Dynamics

Electrophysiology Catheter

Programmed Stimulation

Ventricular Arrhythmogenesis

Multi electrode Array

Chapters in this video

0:04

Title

0:47

Preparation of Langendorff Apparatus & Heart

2:21

Electrophysiological Parameters and Arrhythmogenesis

3:16

Förster Resonance Energy Transfer (FRET)-based Cyclic Adenosine Monophosphate (cAMP) Imaging

4:51

Results: The Langendorff Ex Vivo Heart Perfusion System is Useful to Study the Impact of Intracardiac Electrophysiology and Arrhythmogenesis

6:07

Conclusion

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