Results: Representative Transmembrane Potential and Calcium Transient Mapping
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Conclusion
Transcript
This protocol is significant because it provides researchers with the skills to employ donor human hearts for preclinical physiological drug testing. This tissue utilizes both voltage and calcium dyes for the simultaneous characterization of cardi
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This protocol describes the procedure for sectioning and culturing human cardiac slices for preclinical drug testing and details the use of optical mapping for recording transmembrane voltage and intracellular calcium signals simultaneously from these slices.