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Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

DOI :

10.3791/58229-v

October 30th, 2018

October 30th, 2018

7,618 Views

1Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama

Here a protocol to investigate the early effects of amyloid-β (Aβ) in the brain is presented. This shows that Aβ induces clathrin-mediated endocytosis and collapse of axonal growth cones. The protocol is useful in studying early effects of Aβ on axonal growth cones and may facilitate prevention of Alzheimer's disease.

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