JoVE Logo
Faculty Resource Center

Sign In

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

DOI :

10.3791/52805-v

June 17th, 2015

June 17th, 2015

17,571 Views

1Department of Pathology and Cell Biology, Columbia University Medical Center, 2The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 3Department of Neurology, Columbia University Medical Center

Here, we present a protocol for direct stereotaxic brain infusion of amyloid-beta. This methodology provides an alternative in vivo mouse model to address the short-term effects of amyloid-beta on brain neurons.

Tags

Keywords Alzheimer s Disease

-- Views

Related Videos

article

Visualization and Genetic Manipulation of Dendrites and Spines in the Mouse Cerebral Cortex and Hippocampus using In utero Electroporation

article

Stereotaxic Injection of a Viral Vector for Conditional Gene Manipulation in the Mouse Spinal Cord

article

Building An Open-source Robotic Stereotaxic Instrument

article

Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

article

Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

article

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

article

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

article

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

article

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

article

In Vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved