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Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

DOI :

10.3791/2794-v

July 13th, 2011

July 13th, 2011

34,401 Views

1Department of Physiology, Northwestern University Feinberg School of Medicine, 2Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine

Numerous recent studies have identified mutations in synaptic proteins associated with brain pathologies. Primary cultured cortical neurons offer great flexibility in examining the effects of these disease-associated proteins on dendritic spine morphology and motility.

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Dendritic Spines

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