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A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

DOI :

10.3791/59201-v

5:28 min

August 15th, 2019

August 15th, 2019

21,141 Views

1Department of Bioengineering and Institute of Nanoscience and Technology, Hanyang University, 2Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine

Here, we present a protocol using a mouse positioning device that enables the appropriate placement of mice for the intranasal administration of a brain-targeting peptide-siRNA formulation enabling effective gene silencing in the central nervous system.

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Positioning Device

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