JoVE Logo
Faculty Resource Center

Sign In

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

DOI :

10.3791/58487-v

January 7th, 2019

January 7th, 2019

6,590 Views

1Department of Biomedical Engineering, University of Rochester

We present a method to assess the spatial extent of cell injury/death on the articular surface of intact murine joints after application of controlled mechanical loads or impacts. This method can be used to investigate how osteoarthritis, genetic factors and/or different loading regimens affect the vulnerability of in situ chondrocytes.

Tags

Real time Visualization

-- Views

Related Videos

article

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

article

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

article

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

article

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

article

A Test Bed to Examine Helmet Fit and Retention and Biomechanical Measures of Head and Neck Injury in Simulated Impact

article

Manufacturing of a Nafion-coated, Reduced Graphene Oxide/Polyaniline Chemiresistive Sensor to Monitor pH in Real-time During Microbial Fermentation

article

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

article

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

article

Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

article

Labeling of Extracellular Vesicles for Monitoring Migration and Uptake in Cartilage Explants

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved