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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

DOI :

10.3791/58946-v

8:49 min

January 22nd, 2019

January 22nd, 2019

8,743 Views

1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 2Singapore Immunology Network, A*STAR, 3Curiox Biosystems, 4Department of Immunobiology, Rega Institute for Medical Research, Katholieke Universiteit (KU) Leuven

This paper uses a flow-cytometry-based assay to screen libraries of chemical inhibitors for the identification of inhibitors and their targets that influence T-cell receptor signaling. The methods described here can also be expanded for high-throughput screenings.

Tags

T cell Receptor Signaling

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