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Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung Video (Video) | JoVE

DOI :

10.3791/59450-v

May 20th, 2019

May 20th, 2019

12,716 Views

1Department of Medicine, University of Colorado Denver, 2Department of Medicine, Denver Health Medical Center

Intratracheal (IT) administration of experimental agents in mice often results in asymmetric delivery to the distal lungs.  In this report, we describe a direct intrabronchial (IB) approach to cannulate each lung in living mice non-operatively.  This approach can be used to selectively administer agents to one lung or may be adapted to improve the symmetric agent delivery to both lungs.

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