JoVE Logo
Faculty Resource Center

Sign In

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

DOI :

10.3791/59450-v

May 20th, 2019

May 20th, 2019

12,830 Views

1Department of Medicine, University of Colorado Denver, 2Department of Medicine, Denver Health Medical Center

Intratracheal (IT) administration of experimental agents in mice often results in asymmetric delivery to the distal lungs.  In this report, we describe a direct intrabronchial (IB) approach to cannulate each lung in living mice non-operatively.  This approach can be used to selectively administer agents to one lung or may be adapted to improve the symmetric agent delivery to both lungs.

Tags

Intrabronchial Administration

-- Views

Related Videos

article

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

article

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

article

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung

article

Diagnostic Ultrasound Imaging of Mouse Diaphragm Function

article

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

article

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

article

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

article

Design, Fabrication, and Administration of the Hand Active Sensation Test (HASTe)

article

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

article

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved