Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

8.2K Views

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10:21 min

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August 8th, 2019

DOI :

10.3791/59701-v

August 8th, 2019

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Teresa Mann¹, Jens Kurth², Anne Möller³, Joanna Förster³, Brigitte Vollmar⁴, Bernd J. Krause², Andreas Wree¹, Jan Stenzel*³, Tobias Lindner*³

¹Institute of Anatomy, Rostock University Medical Center, ²Department of Nuclear Medicine, Rostock University Medical Center, ³Core Facility Multimodal Small Animal Imaging, Rostock University Medical Center, ⁴Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Center

Summary

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Continuous Blood Sampling

Small Animal PET CT

Arterial Input Function

Biokinetic Modeling

Protocol Advantages

Reproducibility

Minimal Blood Loss

Temporal Resolution

Activity Concentration

Surgical Procedure

Microsurgical Instruments

Catheter Insertion

Blood Flow Measurement

Chapters in this video

0:04

Title

1:05

Animal Catheterization

3:31

Image Acquisition and Reconstruction

6:41

Manual and Online Blood Sampling

8:31

Results: Representative Continuous and Manual Blood Sampling Results

9:47

Conclusion

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