December 20th, 2019
•Tau is a neuronal protein present both in the cytoplasm, where it binds microtubules, and in the nucleus, where it exerts unconventional functions including the modulation of Alzheimer's disease-related genes. Here, we describe a method to investigate the function of nuclear Tau while excluding any interferences coming from cytoplasmic Tau.
Tags
Related Videos
Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts
Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
Controllable Ion Channel Expression through Inducible Transient Transfection
Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Transient Expression of Foreign Genes in Insect Cells (sf9) for Protein Functional Assay
Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
Exploring the Root Microbiome: Extracting Bacterial Community Data from the Soil, Rhizosphere, and Root Endosphere
qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved