Methods Article

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

2.6K Views

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06:09 min

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November 6th, 2020

DOI :

10.3791/61244-v

November 6th, 2020

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Aric F. Logsdon*¹^,², Brandon P. Lucke-Wold*³, Ryan C. Turner*⁴, Sean M. Collins⁵, Evan L. Reeder⁵, Jason D. Huber⁴, Charles L. Rosen⁶, Matthew J. Robson*⁵, Florian Plattner*⁷

¹Geriatrics Research Education and Clinical Center, Veterans Affairs, ²Division of Gerontology and Geriatric Medicine, University of Washington, ³Department of Neurosurgery, University of Florida, ⁴Department of Neurosurgery, West Virginia University, ⁵Division of Pharmaceutical Sciences, University of Cincinnati, ⁶Central Illinois Neuro Health Sciences, Bloomington, IL, ⁷Neuro-research, Dallas, TX

Summary

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Low intensity Blast Wave Model

Preclinical Assessment

Closed head TBI

Mild Traumatic Brain Injury

Rodent Model

Acceleration deceleration Effects

Sports Injury Simulation

Shock Tube Setup

TBI Sequelae Evaluation

Pressure Sensors

Gas Cylinder Safety

Animal Experiments Protocol

PVC Pipe Shield

Graphical User Interface

Pressure Wave Generation

Chapters in this video

0:04

Introduction

0:53

Installation of the Blast TBI Setup

1:34

Preparation of Experimental Setup and Induction of Mild TBI in Rodents

3:06

Exposure of Rodent to Blast Wave and its Recovery

3:59

Results: Acute In-Vivo Effects of Blast-Induced TBI

5:28

Conclusion

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