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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

DOI :

10.3791/64592-v

January 20th, 2023

January 20th, 2023

1,937 Views

1Division of Medical Sciences, University of Victoria, 2Island Medical Program, University of British Columbia

Here, it is demonstrated how an awake closed-head injury model can be used for examining the effects of repeated mild traumatic brain injury (r-mTBI) on synaptic plasticity in the hippocampus. The model replicates important features of r-mTBI in patients and is used in conjunction with in vitro electrophysiology.

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Awake Closed head Injury Model

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