JoVE Logo
Faculty Resource Center

Sign In

A Novel In Vitro Model of Blast Traumatic Brain Injury

DOI :

10.3791/58400-v

8:59 min

December 21st, 2018

December 21st, 2018

9,733 Views

1Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Imperial College London, 2Royal British Legion Centre for Blast Injury Studies, Department of Bioengineering, Imperial College London, 3Department of Bioengineering, Imperial College London, 4Department of Life Sciences, Imperial College London, 5Department of Anaesthetics, Royal Berkshire Hospital NHS Foundation Trust, 6Royal Centre for Defence Medicine, Medical Directorate Joint Force Command

This paper describes a novel model of primary blast traumatic brain injury. A compressed-air driven shock tube is used to expose in vitro mouse hippocampal slice cultures to a single shock wave. This is a simple and rapid protocol generating a reproducible brain tissue injury with a high throughput.

Tags

Novel In Vitro Model

-- Views

Related Videos

article

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

article

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

article

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus

article

In Vivo Whole-Brain Imaging of Zebrafish Larvae Using Three-Dimensional Fluorescence Microscopy

article

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

article

Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior

article

A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

article

Low-Cost Electroencephalographic Recording System Combined with a Millimeter-Sized Coil to Transcranially Stimulate the Mouse Brain In Vivo

article

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

article

Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved