Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

2.3K Views

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08:43 min

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August 26th, 2021

DOI :

10.3791/62335-v

August 26th, 2021

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Laura Diaz-Maue*¹^,², Janna Steinebach*¹, Michael Schwaerzle⁸^,⁹, Stefan Luther¹^,³^,⁴^,⁶, Patrick Ruther⁸^,⁹, Claudia Richter¹^,⁵^,⁶^,⁷

¹Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, ²Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, ³Department of Pharmacology and Toxicology, University Medical Center Goettingen, ⁴Institute for Nonlinear Dynamics, Georg-August-University Goettingen, ⁵Department of Cardiology and Pneumology, University Medical Center Goettingen, ⁶German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, ⁷Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, ⁸Department of Microsystems Engineering (IMTEK), University of Freiburg, ⁹Cluster of Excellence BrainLinks-BrainTools, University of Freiburg

Summary

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Advanced Cardiac Rhythm Management

Localized Light Stimulation

Experimental Protocol

ECG Electrodes

Multi site Photostimulation

Chapters in this video

0:04

Introduction

0:54

Langendorff Perfusion

2:53

Arrhythmia Induction and Optical Defibrillation

4:41

Optical Mapping

5:45

Results: Analysis of Success Rates and Manipulation of Cardiac Rhythm by Means of Photosimulation

7:56

Conclusion

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