JoVE Logo
Faculty Resource Center

Sign In

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

DOI :

10.3791/62335-v

August 26th, 2021

August 26th, 2021

2,050 Views

1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg

This work reports a method for controlling the cardiac rhythm of intact murine hearts of transgenic channelrhodopsin-2 (ChR2) mice using local photostimulation with a micro-LED array and simultaneous optical mapping of epicardial membrane potential.

-- Views

Related Videos

article

Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy

article

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

article

Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation

article

Intramyocardial Cell Delivery: Observations in Murine Hearts

article

EEG Mu Rhythm in Typical and Atypical Development

article

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts

article

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

article

Cardiac Magnetic Resonance Imaging at 7 Tesla

article

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

article

Isolation and Purification of Murine Cardiac Pericytes

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved