Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

The scope of our research is the detection, diagnosis, and treatment of earlier gastrointestinal tumors. The question I would like to answer is how to predict the risk of pathological escalation of gastric low-grade intraepithelial neoplasia in order to get the diagnosis and best treatment of patients. Recent developments in digestive endoscopy involve minimally invasive techniques, improved imaging modalities, revision biopsies, and robot-assisted surgeries, which improve diagnosis and treatment outcomes.

In the future, we will focus our research scope on how to improve the diagnosis rate of early gastric cancer and includes the diagnostic of early gastric cancer through artificial intelligence as well as advanced endoscopic techniques. To begin, prepare the endoscope for surgical examination. Insert the endoscope through the patient's mouth and gradually advance it through the esophagus into the stomach.

Observe the interior of the digestive tract, examining the color, shape, texture, and distribution of blood vessels in the mucosa to identify possible lesions. Using ME-NBI technology, observe the microstructure of the gastric mucosal surfaces to determine the extent of lesions. After locating the lesion under white light endoscopy, zoom in from far to near the center of the lesion.

Examine the lesion to determine if the demarcation line exists and the extent of anisotropy of the microvascular and structural components. Next, use a disposable mucosal incision knife to make electrocoagulation marks all along the lesion boundary. Inject a prepared solution of saline, epinephrine, and indigo rouge into the submucosa with an endoscopic injection needle.

When the lesion has been completely elevated, make a circumferential incision around the lesion from the marking point. Then, dissect the lesion submucosally until it is completely removed. After dissection, carefully observe the wound.

Electrocoagulate the wound with electrocoagulation forceps. Use the snare to remove the tissue sample after complete excision. Pin the excised needle to a sample board before further tissue processing.