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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

DOI :

10.3791/59236-v

May 12th, 2019

May 12th, 2019

5,647 Views

1Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2Novo Nordisk Foundation Center of Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

Here, we present a protocol to establish important endpoints and proliferative markers of small intestinal injury and compensatory hyperproliferation using a model of chemotherapy-induced mucositis. We demonstrate the detection of proliferating cells using a cell cycle specific marker and using small intestinal weight, crypt depth, and villus height as endpoints.

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Endpoints

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