And here, a high resolution optical coherence tomography, or HROCT, is a promising tool for non-invasively characterizing ocular surface screen errors, neoplasia, or OSSN. It provides an in-vivo transsectional volume of ocular surface lesions, offering an optical biopsy. For OSSN, we presented a standardized, practical, reproducible approach to assist clinicians in managing OSSN in clinical workflows.
HROCT can expandedly assist in guiding the differentiation of OSSN from various ocular lesions. HROCT images of OSSN displaying three distinct features:hyper reflective epithelial thickening, a rapid transition from normal epithelium to abnormal tissue, and a distinct claim between the lesion and underlying tissues. Most non-epithelial derived diseases purely present as normal epithelium with thickening subepithelial lesions.
The imaging biomarkers in a HROCT of OSSN can be extended further in deep learning applications. This can help ophthalmologists increase their diagnostic, prognostic, and monitoring accuracy, as well as decrease workloads and costs.
