Department of Surgery
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Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production.
Journal of virology Jan, 2003 | Pubmed ID: 12477847
Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups.
Journal of virology May, 2004 | Pubmed ID: 15078923
Adeno-associated virus vectors: potential applications for cancer gene therapy.
Cancer gene therapy Dec, 2005 | Pubmed ID: 15962012
Utility of telomerase-pot1 fusion protein in vascular tissue engineering.
Cell transplantation , 2010 | Pubmed ID: 19878625
Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.
Applied and environmental microbiology Jul, 2010 | Pubmed ID: 20472724
Short-lived alpha-helical intermediates in the folding of beta-sheet proteins.
Biochemistry Jul, 2010 | Pubmed ID: 20515035
Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
The Journal of biological chemistry Nov, 2010 | Pubmed ID: 20889505
Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model.
The Journal of thoracic and cardiovascular surgery Dec, 2010 | Pubmed ID: 20934725
AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes.
American journal of physiology. Endocrinology and metabolism May, 2011 | Pubmed ID: 21364119
Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2011 | Pubmed ID: 21896730
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2012 | Pubmed ID: 22068425
X-Linked Inhibitor of Apoptosis Protein-Mediated Attenuation of Apoptosis, Using a Novel Cardiac-Enhanced Adeno-Associated Viral Vector.
Human gene therapy Mar, 2012 | Pubmed ID: 22339372
Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.
Journal of virology Aug, 2012 | Pubmed ID: 22593151
Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction.
Human gene therapy Oct, 2012 | Pubmed ID: 22680698
Gene therapy for the prevention of vein graft disease.
Translational research : the journal of laboratory and clinical medicine Apr, 2013 | Pubmed ID: 23274305
Proteomic analysis of the NOS2 interactome in human airway epithelial cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Nov, 2013 | Pubmed ID: 23438482
Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.
PloS one , 2014 | Pubmed ID: 25117565
Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.
Addiction biology Jan, 2016 | Pubmed ID: 25123018
Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury.
JACC. Heart failure Jan, 2015 | Pubmed ID: 25447345
RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.
Stem cells and development Nov, 2015 | Pubmed ID: 26176491
Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.
Journal of cardiac failure Feb, 2016 | Pubmed ID: 26365053
Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.
Journal of the American College of Cardiology Jan, 2016 | Pubmed ID: 26796394
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.
Scientific reports Sep, 2016 | Pubmed ID: 27670941
Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Sep/Oct, 2017 | Pubmed ID: 28319523
Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
Physiological reports Aug, 2017 | Pubmed ID: 28821596
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
JCI insight Sep, 2017 | Pubmed ID: 28878120
S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence.
Molecular cell May, 2018 | Pubmed ID: 29727618
The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.
American journal of physiology. Heart and circulatory physiology 01, 2019 | Pubmed ID: 30387679
NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase.
Antioxidants & redox signaling 07, 2019 | Pubmed ID: 30450923
A mole rat's gut microbiota suggests selective influence of diet on microbial niche space and evolution.
Experimental biology and medicine (Maywood, N.J.) 04, 2019 | Pubmed ID: 30760029
A normothermic ex vivo organ perfusion delivery method for cardiac transplantation gene therapy.
Scientific reports 05, 2019 | Pubmed ID: 31142753
The use of an inexpensive processing aid device (the Mouse PAD) to facilitate rodent tissue banking.
BioTechniques 07, 2020 | Pubmed ID: 32418443
Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health.
Computational and structural biotechnology journal , 2021 | Pubmed ID: 33552447
Consequences of space radiation on the brain and cardiovascular system.
Journal of environmental science and health. Part C, Toxicology and carcinogenesis , 2021 | Pubmed ID: 33902387
Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure.
Cell death discovery Oct, 2021 | Pubmed ID: 34689154
Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.
Frontiers in cardiovascular medicine , 2022 | Pubmed ID: 35224061
Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.
iScience Apr, 2022 | Pubmed ID: 35378858
Ex Vivo Delivery of Viral Vectors by Organ Perfusion for Cardiac Transplantation Gene Therapy.
Methods in molecular biology (Clifton, N.J.) , 2022 | Pubmed ID: 36040600
Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.
Journal of cardiovascular translational research Jun, 2023 | Pubmed ID: 36344902
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Cell stem cell Jan, 2023 | Pubmed ID: 36516837
Gene Delivery to Porcine Cardiac Allografts Using a Myocardial-Enhanced Adeno-Associated Viral Vector.
Human gene therapy Apr, 2023 | Pubmed ID: 36927038
Video analysis of beating hearts during preservation on the TransMedics® organ care system.
Frontiers in cardiovascular medicine , 2023 | Pubmed ID: 37408655
Metabolomic profiling during ex situ normothermic perfusion before heart transplantation defines patterns of substrate utilization and correlates with markers of allograft injury.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation May, 2024 | Pubmed ID: 38065238
GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
Nature communications Dec, 2023 | Pubmed ID: 38081847
Gene Therapy in Organ Transplantation: Considerations and Clinical Translation.
Human gene therapy Apr, 2024 | Pubmed ID: 38131288
GRAF1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes.
Cells Mar, 2024 | Pubmed ID: 38474413
Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation.
Frontiers in physiology , 2024 | Pubmed ID: 38699144
Cardiac magnetic resonance imaging characterization of acute rejection in a porcine heterotopic heart transplantation model.
PloS one , 2024 | Pubmed ID: 38829911
Deep Learning Resolves Myovascular Dynamics in the Failing Human Heart.
JACC. Basic to translational science May, 2024 | Pubmed ID: 38984052
Comprehensive Flow Cytometric, Immunohistologic, and Molecular Assessment of Thymus Function in Rhesus Macaques.
ImmunoHorizons Jul, 2024 | Pubmed ID: 39018546
Editorial: Graft preservation.
Frontiers in cardiovascular medicine , 2024 | Pubmed ID: 39526188
Current approaches to optimize the donor heart for transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Apr, 2025 | Pubmed ID: 39730081
Michelle Mendiola Pla1,
Amy Evans2,
Franklin H. Lee3,
Yuting Chiang1,
Muath Bishawi1,
Andrew Vekstein1,
Lillian Kang1,
Diego Zapata4,
Ryan Gross3,
Alexis Carnes2,
Lynden E. Gault5,
Julie A. Balko6,
Desiree Bonadonna2,
Sam Ho5,
Paul Lezberg7,
Benjamin S. Bryner1,
Jacob N. Schroder1,
Carmelo A. Milano1,
Dawn E. Bowles3
1Division of Cardiothoracic Surgery, Department of Surgery, Duke University,
2Perfusion Services, Duke University,
3Division of Surgical Sciences, Department of Surgery, Duke University,
4Division of Laboratory Animal Resources, Duke University,
5, Gift of Hope Organ and Tissue Donor Network,
6College of Veterinary Medicine, North Carolina State University,
7, TransMedics, Inc
Krish C. Dewan*,1,
Abigail R. Benkert*,1,
Alejandro A. Lobo1,
Jengwei Chen1,2,
Ryan T. Gross1,
Martha Salinas1,
Amy Evans3,
Satyanarayana Achanta4,
Sachin Mehta4,
Michael Cutrone4,
Violet Johnston1,
Karla Rivera1,
Keely Dieplinh Tran1,
Smith Ngeve1,
Sharon McCartney4,
Carmelo Milano1,
Dawn E. Bowles1,
Jeffrey E. Keenan1
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