JoVE Logo
Faculty Resource Center

Sign In

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

DOI :

10.3791/61740-v

June 4th, 2021

June 4th, 2021

2,027 Views

1Department of Anesthesiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine

Traditional photothrombotic stroke (PTS) models mainly induce dense platelet aggregates of a high resistance to tissue plasminogen activator (tPA)-lytic treatment. Here a modified murine PTS model is introduced by co-injecting thrombin and photosensitive dye for photoactivation. The thrombin-enhanced PTS model produces mixed platelet:fibrin clots and is highly sensitive to tPA-thrombolysis.

-- Views

Related Videos

article

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain

article

Dissection, Culture, and Analysis of Xenopus laevis Embryonic Retinal Tissue

article

A Caenorhabditis elegans Model System for Amylopathy Study

article

Trypsin Digest Protocol to Analyze the Retinal Vasculature of a Mouse Model

article

Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents

article

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery

article

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

article

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

article

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

article

Author Spotlight: Advancing Traumatic Brain Injury Research — A Closed-Head Model for Accurate Replication and Rapid Assessment

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved