Lorne Zinman

ALS/ MN Clinic, Sunnybrook Health Science Centre

Affiliated withSunnybrook Health Science Centre University of Toronto

Research Area

MedicineGenetics

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2011
Publication title	2018

Other Publications

Article	Year
Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes care\| PubMed ID: 15047649	2004
Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: comparison of CASE IV and Medoc instruments. Diabetes care\| PubMed ID: 15220245	2004
Sensitivity of repetitive facial-nerve stimulation in patients with myasthenia gravis. Muscle & nerve\| PubMed ID: 16421884	2006
IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial. Neurology\| PubMed ID: 17353471	2007
Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis. Neurobiology of aging\| PubMed ID: 17383054	2008
Surrogate therapeutic outcome measures in patients with myasthenia gravis. Muscle & nerve\| PubMed ID: 17918748	2008
Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology\| PubMed ID: 18090923	2007
IVIG treatment for myasthenia gravis: effectiveness, limitations, and novel therapeutic strategies. Annals of the New York Academy of Sciences\| PubMed ID: 18567877	2008
Are statin medications safe in patients with ALS? Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases\| PubMed ID: 18608105	2008
Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 19670443	2009
Kinematics of disease progression in bulbar ALS. Journal of communication disorders\| PubMed ID: 19683250	2010
Safety of influenza vaccination in patients with myasthenia gravis: a population-based study. Muscle & nerve\| PubMed ID: 19902540	2009
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form. Acta neuropathologica\| PubMed ID: 20111867	2010
Non-invasive ventilation for Canadian patients with ALS: do we have consensus? The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques\| PubMed ID: 20169767	2010
Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet neurology\| PubMed ID: 20363190	2010
Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease. Journal of neurochemistry\| PubMed ID: 20533992	2010
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS. Molecular and cellular neurosciences\| PubMed ID: 21421050	2011
Emerging targets and treatments in amyotrophic lateral sclerosis. Lancet neurology\| PubMed ID: 21511200	2011
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation. Acta neuropathologica\| PubMed ID: 21604077	2011
Paraspinal myopathy with novel shard-like compact aggregates of thin filaments. Muscle & nerve\| PubMed ID: 21660984	2011
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron\| PubMed ID: 21944779	2011
Tongue movements and their acoustic consequences in amyotrophic lateral sclerosis. Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)\| PubMed ID: 22555651	2012
Investigation of C9orf72 in 4 Neurodegenerative Disorders. Archives of neurology\| PubMed ID: 22964832	2012
Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis. Current opinion in neurology\| PubMed ID: 23160423	2012
Mortality associated with periodic limb movements during sleep in amyotrophic lateral sclerosis patients. Einstein (Sao Paulo, Brazil)\| PubMed ID: 23386081	2012
Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion. American journal of human genetics\| PubMed ID: 23731538	2013
Bulbar and speech motor assessment in ALS: Challenges and future directions. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 23898888	2013
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature neuroscience\| PubMed ID: 24686783	2014
Venous thromboembolism in amyotrophic lateral sclerosis: a prospective study. Neurology\| PubMed ID: 24727309	2014
Hypermethylation of the CpG-island near the C9orf72 G₄C₂-repeat expansion in FTLD patients. Human molecular genetics\| PubMed ID: 24908669	2014
Economic burden of amyotrophic lateral sclerosis: a Canadian study of out-of-pocket expenses. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 25025935	2014
Mutation analysis of patients with neurodegenerative disorders using NeuroX array. Neurobiology of aging\| PubMed ID: 25174650	2015
Identical twins with the C9orf72 repeat expansion are discordant for ALS. Neurology\| PubMed ID: 25209579	2014
Electrical impedance myography in the evaluation of the tongue musculature in amyotrophic lateral sclerosis. Muscle & nerve\| PubMed ID: 25580728	2015
The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients. Acta neuropathologica\| PubMed ID: 25716178	2015
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death. Acta neuropathologica\| PubMed ID: 25788357	2015
Mutation analysis of CHCHD10 in different neurodegenerative diseases. Brain : a journal of neurology\| PubMed ID: 25833818	2015
Jump from pre-mutation to pathologic expansion in C9orf72. American journal of human genetics\| PubMed ID: 26004200	2015
Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 26174152	2015
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. Brain : a journal of neurology\| PubMed ID: 26525917	2016
Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). PloS one\| PubMed ID: 26789001	2016
C9orf72 isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Brain research\| PubMed ID: 27134035	2016
Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. PloS one\| PubMed ID: 27148967	2016
Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 27154192	2016
Physician-assisted death: A Canada-wide survey of ALS health care providers. Neurology\| PubMed ID: 27178703	2016
Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics. Journal of medical speech-language pathology\| PubMed ID: 27453680	2013
Speech Movement Measures as Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis. Journal of speech, language, and hearing research : JSLHR\| PubMed ID: 27679842	2016
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients. Acta neuropathologica\| PubMed ID: 28439722	2017
Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). Journal of Alzheimer's disease : JAD\| PubMed ID: 28671116	2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron\| PubMed ID: 28817800	2017
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis. Human molecular genetics\| PubMed ID: 28973294	2017
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS. Human molecular genetics\| PubMed ID: 29121267	2018
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis. JCI insight\| PubMed ID: 29202456	2017
Clinical and neuropathological features of ALS/FTD with TIA1 mutations. Acta neuropathologica communications\| PubMed ID: 29216908	2017
Unaffected mosaiccase: RNA foci, dipeptide proteins, but upregulated C9orf72 expression. Neurology\| PubMed ID: 29282338	2018
Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis. Muscle & nerve\| PubMed ID: 29381812	2018
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 29434051	2018
Clinical Reasoning: A 42-year-old man with unilateral leg weakness. Neurology\| PubMed ID: 29555890	2018
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron\| PubMed ID: 29566793	2018