ALS/ MN Clinic
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Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial.
Diabetes care Apr, 2004 | Pubmed ID: 15047649
Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: comparison of CASE IV and Medoc instruments.
Diabetes care Jul, 2004 | Pubmed ID: 15220245
Sensitivity of repetitive facial-nerve stimulation in patients with myasthenia gravis.
Muscle & nerve May, 2006 | Pubmed ID: 16421884
IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial.
Neurology Mar, 2007 | Pubmed ID: 17353471
Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.
Neurobiology of aging Aug, 2008 | Pubmed ID: 17383054
Surrogate therapeutic outcome measures in patients with myasthenia gravis.
Muscle & nerve Feb, 2008 | Pubmed ID: 17918748
Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology Dec, 2007 | Pubmed ID: 18090923
IVIG treatment for myasthenia gravis: effectiveness, limitations, and novel therapeutic strategies.
Annals of the New York Academy of Sciences , 2008 | Pubmed ID: 18567877
Are statin medications safe in patients with ALS?
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Aug, 2008 | Pubmed ID: 18608105
Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis.
Annals of neurology Jul, 2009 | Pubmed ID: 19670443
Kinematics of disease progression in bulbar ALS.
Journal of communication disorders Jan-Feb, 2010 | Pubmed ID: 19683250
Safety of influenza vaccination in patients with myasthenia gravis: a population-based study.
Muscle & nerve Dec, 2009 | Pubmed ID: 19902540
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form.
Acta neuropathologica Mar, 2010 | Pubmed ID: 20111867
Non-invasive ventilation for Canadian patients with ALS: do we have consensus?
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Jan, 2010 | Pubmed ID: 20169767
Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.
Lancet neurology May, 2010 | Pubmed ID: 20363190
Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease.
Journal of neurochemistry Aug, 2010 | Pubmed ID: 20533992
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.
Molecular and cellular neurosciences Jul, 2011 | Pubmed ID: 21421050
Emerging targets and treatments in amyotrophic lateral sclerosis.
Lancet neurology May, 2011 | Pubmed ID: 21511200
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation.
Acta neuropathologica Jul, 2011 | Pubmed ID: 21604077
Paraspinal myopathy with novel shard-like compact aggregates of thin filaments.
Muscle & nerve Jul, 2011 | Pubmed ID: 21660984
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.
Neuron Oct, 2011 | Pubmed ID: 21944779
Tongue movements and their acoustic consequences in amyotrophic lateral sclerosis.
Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) , 2012 | Pubmed ID: 22555651
Investigation of C9orf72 in 4 Neurodegenerative Disorders.
Archives of neurology Sep, 2012 | Pubmed ID: 22964832
Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis.
Current opinion in neurology Dec, 2012 | Pubmed ID: 23160423
Mortality associated with periodic limb movements during sleep in amyotrophic lateral sclerosis patients.
Einstein (Sao Paulo, Brazil) Oct-Dec, 2012 | Pubmed ID: 23386081
Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion.
American journal of human genetics Jun, 2013 | Pubmed ID: 23731538
Bulbar and speech motor assessment in ALS: Challenges and future directions.
Amyotrophic lateral sclerosis & frontotemporal degeneration Jul, 2013 | Pubmed ID: 23898888
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.
Nature neuroscience May, 2014 | Pubmed ID: 24686783
Venous thromboembolism in amyotrophic lateral sclerosis: a prospective study.
Neurology May, 2014 | Pubmed ID: 24727309
Hypermethylation of the CpG-island near the C9orf72 G₄C₂-repeat expansion in FTLD patients.
Human molecular genetics Nov, 2014 | Pubmed ID: 24908669
Economic burden of amyotrophic lateral sclerosis: a Canadian study of out-of-pocket expenses.
Amyotrophic lateral sclerosis & frontotemporal degeneration Sep, 2014 | Pubmed ID: 25025935
Mutation analysis of patients with neurodegenerative disorders using NeuroX array.
Neurobiology of aging Jan, 2015 | Pubmed ID: 25174650
Identical twins with the C9orf72 repeat expansion are discordant for ALS.
Neurology Oct, 2014 | Pubmed ID: 25209579
Electrical impedance myography in the evaluation of the tongue musculature in amyotrophic lateral sclerosis.
Muscle & nerve Oct, 2015 | Pubmed ID: 25580728
The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients.
Acta neuropathologica May, 2015 | Pubmed ID: 25716178
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
Acta neuropathologica Jul, 2015 | Pubmed ID: 25788357
Mutation analysis of CHCHD10 in different neurodegenerative diseases.
Brain : a journal of neurology Sep, 2015 | Pubmed ID: 25833818
Jump from pre-mutation to pathologic expansion in C9orf72.
American journal of human genetics Jun, 2015 | Pubmed ID: 26004200
Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis.
Annals of neurology Oct, 2015 | Pubmed ID: 26174152
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Brain : a journal of neurology Jan, 2016 | Pubmed ID: 26525917
Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
PloS one , 2016 | Pubmed ID: 26789001
C9orf72 isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.
Brain research 09, 2016 | Pubmed ID: 27134035
Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems.
PloS one , 2016 | Pubmed ID: 27148967
Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28.
Journal of neurology, neurosurgery, and psychiatry 11, 2016 | Pubmed ID: 27154192
Physician-assisted death: A Canada-wide survey of ALS health care providers.
Neurology Sep, 2016 | Pubmed ID: 27178703
Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics.
Journal of medical speech-language pathology Mar, 2013 | Pubmed ID: 27453680
Speech Movement Measures as Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis.
Journal of speech, language, and hearing research : JSLHR Oct, 2016 | Pubmed ID: 27679842
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients.
Acta neuropathologica Aug, 2017 | Pubmed ID: 28439722
Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI).
Journal of Alzheimer's disease : JAD , 2017 | Pubmed ID: 28671116
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Neuron Aug, 2017 | Pubmed ID: 28817800
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Human molecular genetics Nov, 2017 | Pubmed ID: 28973294
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Human molecular genetics Jan, 2018 | Pubmed ID: 29121267
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis.
JCI insight Nov, 2017 | Pubmed ID: 29202456
Clinical and neuropathological features of ALS/FTD with TIA1 mutations.
Acta neuropathologica communications Dec, 2017 | Pubmed ID: 29216908
Unaffected mosaiccase: RNA foci, dipeptide proteins, but upregulated C9orf72 expression.
Neurology Jan, 2018 | Pubmed ID: 29282338
Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis.
Muscle & nerve Jan, 2018 | Pubmed ID: 29381812
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study.
Journal of neurology, neurosurgery, and psychiatry Feb, 2018 | Pubmed ID: 29434051
Clinical Reasoning: A 42-year-old man with unilateral leg weakness.
Neurology Mar, 2018 | Pubmed ID: 29555890
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Neuron Mar, 2018 | Pubmed ID: 29566793
1Department of Speech-Language Pathology, University of Toronto,
2ALS/ MN Clinic, Sunnybrook Health Science Centre,
3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln,
4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center,
5Department of Neurology, University of Toronto
Allison A. Dilliott1,2,
Sali M.K. Farhan3,
Mahdi Ghani4,
Christine Sato4,
Eric Liang5,
Ming Zhang4,
Adam D. McIntyre1,
Henian Cao1,
Lemuel Racacho6,7,
John F. Robinson1,
Michael J. Strong1,8,
Mario Masellis9,10,
Dennis E. Bulman6,7,
Ekaterina Rogaeva4,
Anthony Lang10,11,
Carmela Tartaglia4,10,
Elizabeth Finger12,13,
Lorne Zinman9,
John Turnbull14,
Morris Freedman10,15,
Rick Swartz9,
Sandra E. Black9,16,
Robert A. Hegele1,2
1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University,
2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University,
3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard,
4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto,
5School of Medicine, Faculty of Health Sciences, Queen's University,
6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa,
7CHEO Research Institute, Faculty of Medicine, University of Ottawa,
8Department of Clinical Neurological Sciences, Western University,
9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto,
10Division of Neurology, Department of Medicine, University of Toronto,
11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital,
12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University,
13Parkwood Institute, St. Joseph's Health Care,
14Department of Medicine, Division of Neurology, McMaster University,
15Division of Neurology, Department of Medicine, Baycrest Health Sciences,
16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto