Mi-Kyung Shin
Department of Medicine
Johns Hopkins University
Mi Kyung Shin is an Research Associate in the Medicine Department, Johns Hopkins university in Baltimore, Maryland. She received her undergraduate and a Ph.D. from Inha University of South Korea.
During Dr. Shin's training, she studied oxidative stress related signaling pathway in vivo and in vitro. As a post-doctoral fellow (2009 to 2016) in Johns Hopkins University, USA, she focused on effects of intermittent hypoxia (IH) on lipid and glucose metabolism and the pathogenesis of obstructive sleep apnea in mice model.
Dr. Shin was recruited as faculty at Johns Hopkins University in 2016, and received a Career Development Award from American Heart Association in 2019. Her research program focus on the mechanisms of leptin-induced hypertension in the carotid bodies.
Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.
European heart journal Mar, 2012 | Pubmed ID: 21478490
Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes.
Journal of applied physiology (Bethesda, Md. : 1985) Sep, 2011 | Pubmed ID: 21737828
Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice.
American journal of physiology. Endocrinology and metabolism Aug, 2012 | Pubmed ID: 22621867
Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.
PloS one , 2012 | Pubmed ID: 23049707
Thermoneutrality modifies the impact of hypoxia on lipid metabolism.
American journal of physiology. Endocrinology and metabolism Feb, 2013 | Pubmed ID: 23249698
Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4.
American journal of respiratory and critical care medicine Jul, 2013 | Pubmed ID: 23328524
Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues.
Journal of lipid research Apr, 2013 | Pubmed ID: 23386706
Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) Oct, 2014 | Pubmed ID: 25103977
The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia.
Respiratory physiology & neurobiology Nov, 2014 | Pubmed ID: 25179887
Intermittent hypoxia-induced glucose intolerance is abolished by α-adrenergic blockade or adrenal medullectomy.
American journal of physiology. Endocrinology and metabolism Dec, 2014 | Pubmed ID: 25315697
Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea.
Sleep Oct, 2015 | Pubmed ID: 26085300
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
Journal of molecular medicine (Berlin, Germany) 03, 2017 | Pubmed ID: 27738746
Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease.
PloS one , 2016 | Pubmed ID: 28030556
Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test.
Journal of applied physiology (Bethesda, Md. : 1985) Apr, 2017 | Pubmed ID: 28104753
High fat diet induces airway hyperresponsiveness in mice.
Scientific reports 04, 2018 | Pubmed ID: 29686414
Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity.
Sleep 08, 2018 | Pubmed ID: 29767787
Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response.
The Journal of physiology Jan, 2019 | Pubmed ID: 30285278
Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity.
American journal of respiratory and critical care medicine Mar, 2019 | Pubmed ID: 30309268
Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet.
Scientific reports Jan, 2019 | Pubmed ID: 30670753
Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.
Circulation research Sep, 2019 | Pubmed ID: 31545149
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