School of Molecular and Cellular Biology,
Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology,
School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology
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Combining density functional theory (DFT) and collision cross-section (CCS) calculations to analyze the gas-phase behaviour of small molecules and their protonation site isomers.
The Analyst Jun, 2016 | Pubmed ID: 27264846
Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein.
Analytical chemistry 09, 2016 | Pubmed ID: 27467405
Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin.
Journal of the American Society for Mass Spectrometry 01, 2017 | Pubmed ID: 27495285
Proton Dynamics in Protein Mass Spectrometry.
The journal of physical chemistry letters Mar, 2017 | Pubmed ID: 28207277
Analyzing complex mixtures of drug-like molecules: Ion mobility as an adjunct to existing liquid chromatography-(tandem) mass spectrometry methods.
Journal of chromatography. A Mar, 2017 | Pubmed ID: 28228233
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.
Molecular cell Mar, 2017 | Pubmed ID: 28306503
AtaT blocks translation initiation by N-acetylation of the initiator tRNA.
Nature chemical biology 06, 2017 | Pubmed ID: 28369041
Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1.
The Journal of biological chemistry 06, 2017 | Pubmed ID: 28487364
Native Mass Spectrometry for the Characterization of Structure and Interactions of Membrane Proteins.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28755371
Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry.
Analytical and bioanalytical chemistry Nov, 2017 | Pubmed ID: 28900708
Advances in native high-performance liquid chromatography and intact mass spectrometry for the characterization of biopharmaceutical products.
Journal of separation science Jan, 2018 | Pubmed ID: 28990739
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.
Nature communications 10, 2017 | Pubmed ID: 29044096
Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes.
Nucleic acids research 01, 2018 | Pubmed ID: 29136196
Evaluation of ion mobility for the separation of glycoconjugate isomers due to different types of sialic acid linkage, at the intact glycoprotein, glycopeptide and glycan level.
Journal of proteomics 02, 2018 | Pubmed ID: 29197583
The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere.
eLife 12, 2017 | Pubmed ID: 29244022
Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes.
Analytical chemistry 02, 2018 | Pubmed ID: 29360341
Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.
Mass spectrometry reviews 11, 2018 | Pubmed ID: 29425406
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Science advances 03, 2018 | Pubmed ID: 29546243
The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.
Redox biology 10, 2018 | Pubmed ID: 30081385
Editorial and Review: 30th ASMS Sanibel Conference on Mass Spectrometry-Computational Modelling in Mass Spectrometry and Ion Mobility: Methods for Ion Structure and Reactivity Determination.
Journal of the American Society for Mass Spectrometry Dec, 2018 | Pubmed ID: 30397862
masstodon: A Tool for Assigning Peaks and Modeling Electron Transfer Reactions in Top-Down Mass Spectrometry.
Analytical chemistry 02, 2019 | Pubmed ID: 30608646
Recommendations for reporting ion mobility Mass Spectrometry measurements.
Mass spectrometry reviews 05, 2019 | Pubmed ID: 30707468
Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.
The Journal of biological chemistry 04, 2019 | Pubmed ID: 30755483
A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT.
Nature communications 02, 2019 | Pubmed ID: 30814507
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.
Scientific reports 02, 2019 | Pubmed ID: 30814575
Thermodynamic Stability of the Transcription Regulator PaaR2 from Escherichia coli O157:H7.
Biophysical journal 04, 2019 | Pubmed ID: 30979547
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.
Analytical chemistry 06, 2019 | Pubmed ID: 31045356
Native Ion Mobility-Mass Spectrometry Reveals the Formation of β-Barrel Shaped Amyloid-β Hexamers in a Membrane-Mimicking Environment.
Journal of the American Chemical Society 07, 2019 | Pubmed ID: 31141355
MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics.
Analytical chemistry 08, 2019 | Pubmed ID: 31283196
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.
Nature communications 07, 2019 | Pubmed ID: 31320618
How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 of .
The Journal of biological chemistry Nov, 2019 | Pubmed ID: 31611236
A cryo-EM grid preparation device for time-resolved structural studies.
IUCrJ Nov, 2019 | Pubmed ID: 31709058
Enhanced oligomerization of full-length RAGE by synergy of the interaction of its domains.
Scientific reports 12, 2019 | Pubmed ID: 31889156
The Escherichia coli RnlA-RnlB toxin-antitoxin complex: production, characterization and crystallization.
Acta crystallographica. Section F, Structural biology communications Jan, 2020 | Pubmed ID: 31929184
Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation.
Biochimica et biophysica acta. Biomembranes 05, 2020 | Pubmed ID: 31945320
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies.
The Biochemical journal 04, 2020 | Pubmed ID: 32167135
Sample deposition onto cryo-EM grids: from sprays to jets and back.
Acta crystallographica. Section D, Structural biology Apr, 2020 | Pubmed ID: 32254058
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.
Nature communications 06, 2020 | Pubmed ID: 32499486
Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data.
Analytical chemistry 08, 2020 | Pubmed ID: 32649184
Computational Strategies and Challenges for Using Native Ion Mobility Mass Spectrometry in Biophysics and Structural Biology.
Analytical chemistry 08, 2020 | Pubmed ID: 32667808
M42 aminopeptidase catalytic site: the structural and functional role of a strictly conserved aspartate residue.
Proteins 12, 2020 | Pubmed ID: 32673419
Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry.
Journal of the American Society for Mass Spectrometry Sep, 2020 | Pubmed ID: 32812765
Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales.
Structure (London, England : 1993) 11, 2020 | Pubmed ID: 32814033
Metal ions shape α-synuclein.
Scientific reports 10, 2020 | Pubmed ID: 33004902
Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry.
Structure (London, England : 1993) 11, 2020 | Pubmed ID: 33065067
Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study.
International journal of molecular sciences Oct, 2020 | Pubmed ID: 33114222
Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds.
Journal of the American Chemical Society 11, 2020 | Pubmed ID: 33166132
Further insights from structural mass spectrometry into endocytosis adaptor protein assemblies.
International journal of mass spectrometry Jan, 2020 | Pubmed ID: 33244295
Aptamer-ligand recognition studied by native ion mobility-mass spectrometry.
Talanta Mar, 2021 | Pubmed ID: 33379118
Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
Journal of molecular biology 03, 2021 | Pubmed ID: 33422522
Cryo-EM structure of human mitochondrial HSPD1.
iScience Jan, 2021 | Pubmed ID: 33506187
Unveiling the binding mode of perfluorooctanoic acid to human serum albumin.
Protein science : a publication of the Protein Society 04, 2021 | Pubmed ID: 33550662
Interrogating Membrane Protein Structure and Lipid Interactions by Native Mass Spectrometry.
Methods in molecular biology (Clifton, N.J.) , 2020 | Pubmed ID: 33582995
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.
Journal of molecular biology 04, 2021 | Pubmed ID: 33610557
A model of full-length RAGE in complex with S100B.
Structure (London, England : 1993) Sep, 2021 | Pubmed ID: 33887170
Structural modeling of a novel membrane-bound globin-coupled sensor in .
Computational and structural biotechnology journal , 2021 | Pubmed ID: 33995893
Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis.
Nature communications 05, 2021 | Pubmed ID: 34001871
Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin.
Acta crystallographica. Section D, Structural biology Jul, 2021 | Pubmed ID: 34196617
Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry.
Antioxidants (Basel, Switzerland) Jun, 2021 | Pubmed ID: 34206096
Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops.
eLife 07, 2021 | Pubmed ID: 34279225
On-grid and in-flow mixing for time-resolved cryo-EM.
Acta crystallographica. Section D, Structural biology Oct, 2021 | Pubmed ID: 34605427
Nanobody-aided crystallization of the transcription regulator PaaR2 from Escherichia coli O157:H7.
Acta crystallographica. Section F, Structural biology communications Oct, 2021 | Pubmed ID: 34605442
1School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds,
2School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds,
3Department of Physiological Sciences, Eastern Virginia Medical School
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