Department of Pathology
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Activation of c-Jun amino-terminal kinase by GDNF induces G2/M cell cycle delay linked with actin reorganization.
Genes to cells : devoted to molecular & cellular mechanisms Jul, 2005 | Pubmed ID: 15966897
GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region.
Nucleic acids research , 2005 | Pubmed ID: 16049025
Akt/PKB regulates actin organization and cell motility via Girdin/APE.
Developmental cell Sep, 2005 | Pubmed ID: 16139227
RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.
Pathology international Apr, 2006 | Pubmed ID: 16634961
Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.
Journal of cell science Aug, 2006 | Pubmed ID: 16820412
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.
Development (Cambridge, England) Nov, 2006 | Pubmed ID: 17050626
Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways.
Annals of the New York Academy of Sciences Nov, 2006 | Pubmed ID: 17185515
Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.
Cancer science Jun, 2007 | Pubmed ID: 17388787
Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation.
Experimental cell research Oct, 2007 | Pubmed ID: 17674968
Roles of organic anion transporters in the progression of chronic renal failure.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Oct, 2007 | Pubmed ID: 17976081
A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1.
Biochemical and biophysical research communications Feb, 2008 | Pubmed ID: 18060868
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.
Nature cell biology Mar, 2008 | Pubmed ID: 18264090
An actin-binding protein Girdin regulates the motility of breast cancer cells.
Cancer research Mar, 2008 | Pubmed ID: 18316593
GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.
Genes to cells : devoted to molecular & cellular mechanisms Apr, 2008 | Pubmed ID: 18363967
[Coordination of actin cytoskeleton and membrane transport in cell migration].
Seikagaku. The Journal of Japanese Biochemical Society Mar, 2008 | Pubmed ID: 18411793
CD109 expression in basal-like breast carcinoma.
Pathology international May, 2008 | Pubmed ID: 18429827
Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton.
Cancer letters Nov, 2009 | Pubmed ID: 19303207
Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.
Cancer research Apr, 2009 | Pubmed ID: 19351825
Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1.
FEBS letters Aug, 2009 | Pubmed ID: 19596003
Expression of Ret finger protein correlates with outcomes in endometrial cancer.
Cancer science Oct, 2009 | Pubmed ID: 19650860
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Neuron Sep, 2009 | Pubmed ID: 19778507
Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis.
Cancer science Apr, 2010 | Pubmed ID: 20132219
Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
Cancer science May, 2010 | Pubmed ID: 20210798
Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation.
American journal of nephrology , 2010 | Pubmed ID: 20389059
Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.
American journal of physiology. Cell physiology Nov, 2010 | Pubmed ID: 20720180
Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.
Developmental biology Jan, 2011 | Pubmed ID: 21070764
Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.
Molecular biology of the cell Mar, 2011 | Pubmed ID: 21289099
Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.
Human pathology Jun, 2011 | Pubmed ID: 21292309
Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.
American journal of nephrology , 2011 | Pubmed ID: 21389697
[Roles of DISC1-interacting protein Girdin in postnatal development and adult neurogenesis in the dentate gyrus].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Feb, 2011 | Pubmed ID: 21409841
The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
Circulation research May, 2011 | Pubmed ID: 21415395
NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1).
Journal of neurochemistry Jul, 2011 | Pubmed ID: 21517847
Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2011 | Pubmed ID: 21632933
NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.
American journal of physiology. Cell physiology Nov, 2011 | Pubmed ID: 21832251
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.
Human molecular genetics Dec, 2011 | Pubmed ID: 21903668
Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.
American journal of physiology. Cell physiology Jul, 2012 | Pubmed ID: 22555846
Involvement of Girdin in the determination of cell polarity during cell migration.
PloS one , 2012 | Pubmed ID: 22574214
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.
Nature communications May, 2012 | Pubmed ID: 22643886
Epidermal hyperplasia and appendage abnormalities in mice lacking CD109.
The American journal of pathology Oct, 2012 | Pubmed ID: 22846721
Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage.
Biochemical and biophysical research communications Oct, 2012 | Pubmed ID: 22974978
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.
The American journal of pathology Feb, 2013 | Pubmed ID: 23195430
Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer.
Cancer medicine Oct, 2012 | Pubmed ID: 23342271
Metamorphosis of mesothelial cells with active horizontal motility in tissue culture.
Scientific reports , 2013 | Pubmed ID: 23359855
The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.
The Journal of biological chemistry Apr, 2013 | Pubmed ID: 23463509
Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.
Life sciences Jul, 2013 | Pubmed ID: 23702423
Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure.
Journal of vascular surgery Aug, 2014 | Pubmed ID: 23948670
Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy.
PloS one , 2013 | Pubmed ID: 24282602
Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells.
Cancer science May, 2014 | Pubmed ID: 24597627
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Endocrinology May, 2014 | Pubmed ID: 24601883
High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt.
Journal of diabetes investigation Aug, 2011 | Pubmed ID: 24843496
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
The EMBO journal Sep, 2014 | Pubmed ID: 25061227
Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency.
Endocrine journal , 2015 | Pubmed ID: 25346144
Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2014 | Pubmed ID: 25378165
Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.
Biochemical and biophysical research communications Mar, 2015 | Pubmed ID: 25707853
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
Cancer research Mar, 2015 | Pubmed ID: 25732845
New endoplasmic reticulum stress regulator, Gipie, regulates the survival of vascular smooth muscle cells and the neointima formation after vascular injury.
Arteriosclerosis, thrombosis, and vascular biology May, 2015 | Pubmed ID: 25792451
Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice.
The Journal of biological chemistry May, 2015 | Pubmed ID: 25847236
Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.
Biochemical and biophysical research communications May, 2015 | Pubmed ID: 25869066
Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis.
The Journal of clinical endocrinology and metabolism Jul, 2015 | Pubmed ID: 25919460
Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin.
Biochemical and biophysical research communications Aug, 2015 | Pubmed ID: 26072378
Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
Journal of molecular and cellular cardiology Nov, 2015 | Pubmed ID: 26393439
Role for Daple in non-canonical Wnt signaling during gastric cancer invasion and metastasis.
Cancer science Feb, 2016 | Pubmed ID: 26577606
Akt-Girdin as oncotarget.
Oncoscience , 2015 | Pubmed ID: 26682257
Collective invasion of cancer: Perspectives from pathology and development.
Pathology international Apr, 2016 | Pubmed ID: 26897041
Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.
Scientific reports Feb, 2016 | Pubmed ID: 26924503
Ectodermal Dysplasia: Management of Knife-Edged Irregular Ridge and Its Rehabilitation with Hybrid Implant Prosthesis.
Journal of clinical and diagnostic research : JCDR May, 2016 | Pubmed ID: 27437373
Clinicopathological and Immunohistochemical Characteristics of Verruciform Xanthoma of the Lower Gingiva: A Case Report.
Journal of clinical and diagnostic research : JCDR Jun, 2016 | Pubmed ID: 27504422
Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues.
Biochemical and biophysical research communications 09, 2016 | Pubmed ID: 27565725
High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway.
Archives of biochemistry and biophysics Nov, 2016 | Pubmed ID: 27693038
Suppression of skin tumorigenesis in CD109-deficient mice.
Oncotarget Dec, 2016 | Pubmed ID: 27756876
Well-differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration.
Pathology international Dec, 2016 | Pubmed ID: 27862661
A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa.
Journal of clinical and diagnostic research : JCDR Nov, 2016 | Pubmed ID: 28050512
Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 06, 2017 | Pubmed ID: 28375676
Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells.
Neuro-oncology 05, 2017 | Pubmed ID: 28453744
Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.
The Journal of pathology Dec, 2017 | Pubmed ID: 28888050
ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer.
Cancer science Jan, 2018 | Pubmed ID: 29151270
Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells.
Endocrine journal Mar, 2018 | Pubmed ID: 29367474
Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis.
The Journal of pathology Jan, 2018 | Pubmed ID: 29377134
Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note.
Pathology international Feb, 2018 | Pubmed ID: 29465759
Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
Biochemical and biophysical research communications 04, 2018 | Pubmed ID: 29518391
Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.
PLoS biology Mar, 2018 | Pubmed ID: 29538402
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure.
Scientific reports 05, 2018 | Pubmed ID: 29739947
CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo.
Genes to cells : devoted to molecular & cellular mechanisms Jul, 2018 | Pubmed ID: 29767469
Trefoil factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm.
The Journal of clinical investigation 08, 2018 | Pubmed ID: 29809170
Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization.
Cancer science Nov, 2018 | Pubmed ID: 30194792
A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology May, 2019 | Pubmed ID: 30406702
Chemerin promotes angiogenesis in vivo.
Physiological reports Dec, 2018 | Pubmed ID: 30588761
Cancer-associated fibroblasts in gastrointestinal cancer.
Nature reviews. Gastroenterology & hepatology 05, 2019 | Pubmed ID: 30778141
Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.
Biochemical and biophysical research communications 05, 2019 | Pubmed ID: 30935690
CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis.
Pathology international May, 2019 | Pubmed ID: 31219232
Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.
Circulation research 08, 2019 | Pubmed ID: 31221024
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
The Journal of clinical investigation 07, 2019 | Pubmed ID: 31355778
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Cancer research 10, 2019 | Pubmed ID: 31439548
Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives.
Cancer science Apr, 2020 | Pubmed ID: 32060987
Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma.
Oncology reports Sep, 2020 | Pubmed ID: 32705221
Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells.
Cancer science Nov, 2020 | Pubmed ID: 32875699
The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Biochemical and biophysical research communications 11, 2020 | Pubmed ID: 32888647
Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice.
Angiogenesis 02, 2021 | Pubmed ID: 32918673
CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling.
Cancer science Dec, 2020 | Pubmed ID: 33007133
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
Gastroenterology 03, 2021 | Pubmed ID: 33197448
Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma.
Molecular therapy oncolytics Mar, 2021 | Pubmed ID: 33665360
Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.
Genes to cells : devoted to molecular & cellular mechanisms Jul, 2021 | Pubmed ID: 33960573
CD4 T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice.
Science translational medicine 05, 2021 | Pubmed ID: 33980577
The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Aug, 2021 | Pubmed ID: 34029949
A new primate model of hypophyseal dysfunction.
Scientific reports May, 2021 | Pubmed ID: 34031474
Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis.
The European respiratory journal May, 2021 | Pubmed ID: 34049947
The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.
Current biology : CB Jul, 2021 | Pubmed ID: 34087104
Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages.
Particle and fibre toxicology 06, 2021 | Pubmed ID: 34134732
The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.
Development (Cambridge, England) 07, 2021 | Pubmed ID: 34184027
Newly Established Patient-derived Organoid Model of Intracranial Meningioma.
Neuro-oncology Jul, 2021 | Pubmed ID: 34214169
Hiroki Kobayashi1,2,3,4,
Krystyna A. Gieniec1,2,
Jia Q. Ng1,2,
Jarrad Goyne1,2,
Tamsin R. M. Lannagan1,2,
Elaine M. Thomas1,2,
Georgette Radford1,2,
Tongtong Wang1,2,
Nobumi Suzuki1,2,5,
Mari Ichinose1,2,
Josephine A. Wright2,
Laura Vrbanac1,2,
Alastair D. Burt6,
Masahide Takahashi3,4,7,
Atsushi Enomoto3,
Daniel L. Worthley2,
Susan L. Woods1,2
1Adelaide Medical School, University of Adelaide,
2, South Australian Health and Medical Research Institute (SAHMRI),
3Department of Pathology, Nagoya University Graduate School of Medicine,
4Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine,
5Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo,
6Translational and Clinical Research Institute, Newcastle University,
7International Center for Cell and Gene Therapy, Fujita Health University
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