Department of Pathology,
Division of Molecular Pathology,
Center for Neurological Disease and Cancer,
Division of Molecular Pathology, Center for Neurological Disease and Cancer
I graduated from Nagoya University School of Medicine in 1979. I majored in Pathology at Nagoya University Graduate School of Medicine and received PhD degree in 1983. Then I studied as a research fellow at Dana-Farber Cancer Institute and Harvard Medical School in Boston between 1983 and 1985. After returning to Japan, I worked as a researcher at Aichi Cancer Center Research Institute in Nagoya between 1985 and 1990, and moved to Nagoya University as Assistant Professor. I became Professor of Pathology at Nagoya University in 1996. I was appointed to be Dean of Nagoya University School of Medicine between 2012 and 2017, and Trustee and Vice President of Nagoya University between 2017 and 2020. I became Director and Professor of International Center for Cell and Gene Therapy at Fujita Health University in 2020.
The GDNF/RET signaling pathway and human diseases.
Cytokine & growth factor reviews Dec, 2001 | Pubmed ID: 11544105
Role for O-glycosylation of RFP in the interaction with enhancer of polycomb.
Biochemical and biophysical research communications Jan, 2002 | Pubmed ID: 11779184
Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11886862
Evidence of both extra- and intracellular cysteine targets of protein modification for activation of RET kinase.
Biochemical and biophysical research communications Apr, 2002 | Pubmed ID: 11944888
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Cancer research Apr, 2002 | Pubmed ID: 11956105
Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways.
Biochemical and biophysical research communications Jun, 2002 | Pubmed ID: 12056817
Role of Dok1 in cell signaling mediated by RET tyrosine kinase.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12087092
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.
The American journal of pathology Jul, 2002 | Pubmed ID: 12107109
Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2002 | Pubmed ID: 12409318
Differential expression of RET finger protein in testicular germ cell tumors.
Pathology international Oct, 2002 | Pubmed ID: 12445133
Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease.
European journal of human genetics : EJHG May, 2003 | Pubmed ID: 12734540
Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.
The Journal of biological chemistry Dec, 2003 | Pubmed ID: 14522971
Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.
The Journal of biological chemistry Dec, 2003 | Pubmed ID: 14530259
Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation.
Cancer science Nov, 2003 | Pubmed ID: 14611677
Identification of RET autophosphorylation sites by mass spectrometry.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14711813
c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model.
Cancer research Feb, 2004 | Pubmed ID: 14871802
RET and neuroendocrine tumors.
Cancer letters Feb, 2004 | Pubmed ID: 15013219
Expression of CD109 in human cancer.
Oncogene Apr, 2004 | Pubmed ID: 15116102
Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region.
Biochemical and biophysical research communications Jul, 2004 | Pubmed ID: 15207709
Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector.
Biochemical and biophysical research communications Jul, 2004 | Pubmed ID: 15240136
A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.
Molecular and cellular biology Sep, 2004 | Pubmed ID: 15340065
Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells.
Biochemical and biophysical research communications Oct, 2004 | Pubmed ID: 15351743
Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties.
Cancer science Oct, 2004 | Pubmed ID: 15504249
Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice.
Biochemical and biophysical research communications Dec, 2004 | Pubmed ID: 15555549
The RET proto-oncogene: a molecular therapeutic target in thyroid cancer.
Cancer science Mar, 2005 | Pubmed ID: 15771616
CD109 expression in squamous cell carcinoma of the uterine cervix.
Pathology international Apr, 2005 | Pubmed ID: 15826242
PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.
Experimental cell research Aug, 2005 | Pubmed ID: 15907835
Activation of c-Jun amino-terminal kinase by GDNF induces G2/M cell cycle delay linked with actin reorganization.
Genes to cells : devoted to molecular & cellular mechanisms Jul, 2005 | Pubmed ID: 15966897
GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region.
Nucleic acids research , 2005 | Pubmed ID: 16049025
Akt/PKB regulates actin organization and cell motility via Girdin/APE.
Developmental cell Sep, 2005 | Pubmed ID: 16139227
Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16186106
A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.
FEBS letters Feb, 2006 | Pubmed ID: 16427628
Analyses of ultraviolet-induced focus formation of hREV1 protein.
Genes to cells : devoted to molecular & cellular mechanisms Mar, 2006 | Pubmed ID: 16483309
RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.
Pathology international Apr, 2006 | Pubmed ID: 16634961
Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.
Journal of cell science Aug, 2006 | Pubmed ID: 16820412
RET and neuroendocrine tumors.
Pituitary , 2006 | Pubmed ID: 17036197
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.
Development (Cambridge, England) Nov, 2006 | Pubmed ID: 17050626
Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways.
Annals of the New York Academy of Sciences Nov, 2006 | Pubmed ID: 17185515
Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.
Cancer science Jun, 2007 | Pubmed ID: 17388787
Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a.
The Biochemical journal Jul, 2007 | Pubmed ID: 17439403
CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells.
Pathology international May, 2007 | Pubmed ID: 17493171
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Journal of neurochemistry Sep, 2007 | Pubmed ID: 17555548
Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation.
Experimental cell research Oct, 2007 | Pubmed ID: 17674968
Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities.
Nucleic acids research , 2007 | Pubmed ID: 17884914
High-level expression of CD109 is frequently detected in lung squamous cell carcinomas.
Pathology international Nov, 2007 | Pubmed ID: 17922683
A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1.
Biochemical and biophysical research communications Feb, 2008 | Pubmed ID: 18060868
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.
Nature cell biology Mar, 2008 | Pubmed ID: 18264090
An actin-binding protein Girdin regulates the motility of breast cancer cells.
Cancer research Mar, 2008 | Pubmed ID: 18316593
GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.
Genes to cells : devoted to molecular & cellular mechanisms Apr, 2008 | Pubmed ID: 18363967
CD109 expression in basal-like breast carcinoma.
Pathology international May, 2008 | Pubmed ID: 18429827
Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity.
Cancer science Oct, 2008 | Pubmed ID: 19016750
Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton.
Cancer letters Nov, 2009 | Pubmed ID: 19303207
Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.
Cancer research Apr, 2009 | Pubmed ID: 19351825
Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1.
FEBS letters Aug, 2009 | Pubmed ID: 19596003
Expression of Ret finger protein correlates with outcomes in endometrial cancer.
Cancer science Oct, 2009 | Pubmed ID: 19650860
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.
Developmental cell Aug, 2009 | Pubmed ID: 19686681
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Neuron Sep, 2009 | Pubmed ID: 19778507
Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.
Nature genetics Dec, 2009 | Pubmed ID: 19898483
Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis.
Cancer science Apr, 2010 | Pubmed ID: 20132219
Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
Cancer science May, 2010 | Pubmed ID: 20210798
c-Ret-mediated hearing loss in mice with Hirschsprung disease.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2010 | Pubmed ID: 20616061
Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression.
Pathology international Nov, 2010 | Pubmed ID: 20946523
Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.
Developmental biology Jan, 2011 | Pubmed ID: 21070764
Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.
Molecular biology of the cell Mar, 2011 | Pubmed ID: 21289099
Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.
Human pathology Jun, 2011 | Pubmed ID: 21292309
The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
Circulation research May, 2011 | Pubmed ID: 21415395
Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2011 | Pubmed ID: 21632933
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.
Human molecular genetics Dec, 2011 | Pubmed ID: 21903668
Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane.
Toxicology and applied pharmacology Nov, 2011 | Pubmed ID: 21925529
Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress.
Endocrinology Dec, 2011 | Pubmed ID: 21971157
Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration.
PloS one , 2011 | Pubmed ID: 22216253
RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations.
Pathology international May, 2012 | Pubmed ID: 22524660
Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.
American journal of physiology. Cell physiology Jul, 2012 | Pubmed ID: 22555846
Involvement of Girdin in the determination of cell polarity during cell migration.
PloS one , 2012 | Pubmed ID: 22574214
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.
Nature communications May, 2012 | Pubmed ID: 22643886
Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.
The Journal of biological chemistry Jul, 2012 | Pubmed ID: 22665485
Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.
Toxicology Dec, 2012 | Pubmed ID: 22824114
Epidermal hyperplasia and appendage abnormalities in mice lacking CD109.
The American journal of pathology Oct, 2012 | Pubmed ID: 22846721
Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage.
Biochemical and biophysical research communications Oct, 2012 | Pubmed ID: 22974978
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.
The American journal of pathology Feb, 2013 | Pubmed ID: 23195430
Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer.
Cancer medicine Oct, 2012 | Pubmed ID: 23342271
The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.
The Journal of biological chemistry Apr, 2013 | Pubmed ID: 23463509
The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression.
Journal of cell science Aug, 2013 | Pubmed ID: 23704356
Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines.
Pathogens and disease Feb, 2014 | Pubmed ID: 23929604
Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure.
Journal of vascular surgery Aug, 2014 | Pubmed ID: 23948670
The impact of Girdin expression on recurrence-free survival in patients with luminal-type breast cancer.
Breast cancer (Tokyo, Japan) Sep, 2015 | Pubmed ID: 24155038
Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy.
PloS one , 2013 | Pubmed ID: 24282602
Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.
Molecular and cellular biochemistry Apr, 2014 | Pubmed ID: 24337944
Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice.
PloS one , 2014 | Pubmed ID: 24400073
Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells.
Cancer science May, 2014 | Pubmed ID: 24597627
TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives.
Cell reports May, 2014 | Pubmed ID: 24794433
High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt.
Journal of diabetes investigation Aug, 2011 | Pubmed ID: 24843496
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
The EMBO journal Sep, 2014 | Pubmed ID: 25061227
Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice.
Endocrinology Dec, 2014 | Pubmed ID: 25203138
Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2014 | Pubmed ID: 25378165
Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition.
Experimental cell research Mar, 2015 | Pubmed ID: 25523619
SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling.
The FEBS journal Apr, 2015 | Pubmed ID: 25662172
Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.
Biochemical and biophysical research communications Mar, 2015 | Pubmed ID: 25707853
CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells.
Biochemical and biophysical research communications Apr, 2015 | Pubmed ID: 25724945
Evaluation of androgen receptor and GATA binding protein 3 as immunohistochemical markers in the diagnosis of metastatic breast carcinoma to the lung.
Pathology international Jun, 2015 | Pubmed ID: 25727644
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
Cancer research Mar, 2015 | Pubmed ID: 25732845
New endoplasmic reticulum stress regulator, Gipie, regulates the survival of vascular smooth muscle cells and the neointima formation after vascular injury.
Arteriosclerosis, thrombosis, and vascular biology May, 2015 | Pubmed ID: 25792451
Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.
Biochemical and biophysical research communications May, 2015 | Pubmed ID: 25869066
Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis.
The Journal of clinical endocrinology and metabolism Jul, 2015 | Pubmed ID: 25919460
Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin.
Biochemical and biophysical research communications Aug, 2015 | Pubmed ID: 26072378
A Novel Approach against Vascular Intimal Hyperplasia Through the Suppression of Girdin.
Annals of vascular diseases , 2015 | Pubmed ID: 26131024
Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
Journal of molecular and cellular cardiology Nov, 2015 | Pubmed ID: 26393439
Role for Daple in non-canonical Wnt signaling during gastric cancer invasion and metastasis.
Cancer science Feb, 2016 | Pubmed ID: 26577606
Akt-Girdin as oncotarget.
Oncoscience , 2015 | Pubmed ID: 26682257
CD109 is a component of exosome secreted from cultured cells.
Biochemical and biophysical research communications Jan, 2016 | Pubmed ID: 26707640
Collective invasion of cancer: Perspectives from pathology and development.
Pathology international Apr, 2016 | Pubmed ID: 26897041
CCDC88A mutations cause PEHO-like syndrome in humans and mouse.
Brain : a journal of neurology Apr, 2016 | Pubmed ID: 26917597
Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.
Scientific reports Feb, 2016 | Pubmed ID: 26924503
Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.
International journal of oncology Oct, 2016 | Pubmed ID: 27499036
Suppression of skin tumorigenesis in CD109-deficient mice.
Oncotarget Dec, 2016 | Pubmed ID: 27756876
Well-differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration.
Pathology international Dec, 2016 | Pubmed ID: 27862661
[Corrigendum] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.
International journal of oncology Feb, 2017 | Pubmed ID: 27959390
Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 06, 2017 | Pubmed ID: 28375676
Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells.
Neuro-oncology 05, 2017 | Pubmed ID: 28453744
Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.
Cell reports Jul, 2017 | Pubmed ID: 28746879
Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.
The Journal of pathology Dec, 2017 | Pubmed ID: 28888050
ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer.
Cancer science Jan, 2018 | Pubmed ID: 29151270
Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis.
The Journal of pathology Jan, 2018 | Pubmed ID: 29377134
Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note.
Pathology international Feb, 2018 | Pubmed ID: 29465759
Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.
PLoS biology Mar, 2018 | Pubmed ID: 29538402
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure.
Scientific reports 05, 2018 | Pubmed ID: 29739947
CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo.
Genes to cells : devoted to molecular & cellular mechanisms Jul, 2018 | Pubmed ID: 29767469
Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing.
Journal of cell science 06, 2018 | Pubmed ID: 29777035
Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization.
Cancer science Nov, 2018 | Pubmed ID: 30194792
Chemerin promotes angiogenesis in vivo.
Physiological reports Dec, 2018 | Pubmed ID: 30588761
Cancer-associated fibroblasts in gastrointestinal cancer.
Nature reviews. Gastroenterology & hepatology 05, 2019 | Pubmed ID: 30778141
Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.
Biochemical and biophysical research communications 05, 2019 | Pubmed ID: 30935690
CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis.
Pathology international May, 2019 | Pubmed ID: 31219232
Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.
Circulation research 08, 2019 | Pubmed ID: 31221024
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Cancer research 10, 2019 | Pubmed ID: 31439548
The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness.
Anticancer research Jan, 2020 | Pubmed ID: 31892568
Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives.
Cancer science Apr, 2020 | Pubmed ID: 32060987
Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells.
iScience Jun, 2020 | Pubmed ID: 32535020
Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors.
Cancer letters 10, 2020 | Pubmed ID: 32553781
Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma.
Oral diseases Apr, 2021 | Pubmed ID: 32688445
Intracellular RET signaling pathways activated by GDNF.
Cell and tissue research Oct, 2020 | Pubmed ID: 32816064
Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells.
Cancer science Nov, 2020 | Pubmed ID: 32875699
The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Biochemical and biophysical research communications 11, 2020 | Pubmed ID: 32888647
CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling.
Cancer science Dec, 2020 | Pubmed ID: 33007133
Roles of the Proto-oncogene in Cancer and Development.
JMA journal Jul, 2020 | Pubmed ID: 33150251
Hair graying with aging in mice carrying oncogenic RET.
Aging cell 11, 2020 | Pubmed ID: 33159498
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
Gastroenterology 03, 2021 | Pubmed ID: 33197448
Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.
Cancer science Apr, 2021 | Pubmed ID: 33506575
Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome.
The Journal of biological chemistry Jan-Jun, 2021 | Pubmed ID: 33561442
Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.
Genes to cells : devoted to molecular & cellular mechanisms Jul, 2021 | Pubmed ID: 33960573
CD4 T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice.
Science translational medicine 05, 2021 | Pubmed ID: 33980577
Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis.
The European respiratory journal May, 2021 | Pubmed ID: 34049947
Hiroki Kobayashi1,2,3,4,
Krystyna A. Gieniec1,2,
Jia Q. Ng1,2,
Jarrad Goyne1,2,
Tamsin R. M. Lannagan1,2,
Elaine M. Thomas1,2,
Georgette Radford1,2,
Tongtong Wang1,2,
Nobumi Suzuki1,2,5,
Mari Ichinose1,2,
Josephine A. Wright2,
Laura Vrbanac1,2,
Alastair D. Burt6,
Masahide Takahashi3,4,7,
Atsushi Enomoto3,
Daniel L. Worthley2,
Susan L. Woods1,2
1Adelaide Medical School, University of Adelaide,
2, South Australian Health and Medical Research Institute (SAHMRI),
3Department of Pathology, Nagoya University Graduate School of Medicine,
4Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine,
5Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo,
6Translational and Clinical Research Institute, Newcastle University,
7International Center for Cell and Gene Therapy, Fujita Health University
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