Florey Institute of Neuroscience and Mental Health
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Direct cardiac and vascular actions of adrenomedullin in conscious sheep.
British journal of pharmacology Mar, 1997 | Pubmed ID: 9134233
Aldosterone acts on the kidney, not the brain, to cause mineralocorticoid hypertension in sheep.
Journal of hypertension Jun, 2002 | Pubmed ID: 12023692
Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions.
Hypertension (Dallas, Tex. : 1979) Sep, 2003 | Pubmed ID: 12885791
Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep.
American journal of physiology. Regulatory, integrative and comparative physiology Jun, 2004 | Pubmed ID: 14751846
Selective vasodilator and chronotropic actions of 3',4'-dihydroxyflavonol in conscious sheep.
European journal of pharmacology Apr, 2004 | Pubmed ID: 15102532
3',4'-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep.
British journal of pharmacology Jun, 2004 | Pubmed ID: 15148246
Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus.
Regulatory peptides Oct, 2004 | Pubmed ID: 15380925
Urotensin II, a novel peptide in central and peripheral cardiovascular control.
Peptides Oct, 2004 | Pubmed ID: 15476943
The haemodynamic and metabolic effects of epinephrine in experimental hyperdynamic septic shock.
Intensive care medicine Mar, 2005 | Pubmed ID: 15711973
Differential regional haemodynamic changes during mineralocorticoid hypertension.
Journal of hypertension Jun, 2006 | Pubmed ID: 16685214
Renal vascular resistance in sepsis.
Nephron. Physiology , 2006 | Pubmed ID: 16691034
The effect of normal saline resuscitation on vital organ blood flow in septic sheep.
Intensive care medicine Aug, 2006 | Pubmed ID: 16775719
Urinary biomarkers in septic acute kidney injury.
Intensive care medicine Jul, 2007 | Pubmed ID: 17487471
The histopathology of septic acute kidney injury: a systematic review.
Critical care (London, England) , 2008 | Pubmed ID: 18325092
Responses of cardiac sympathetic nerve activity to changes in circulating volume differ in normal and heart failure sheep.
American journal of physiology. Regulatory, integrative and comparative physiology Sep, 2008 | Pubmed ID: 18635453
Basis for the preferential activation of cardiac sympathetic nerve activity in heart failure.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2009 | Pubmed ID: 19136635
Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep.
American journal of physiology. Regulatory, integrative and comparative physiology Nov, 2009 | Pubmed ID: 19726712
3',4'-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7days reperfusion in sheep.
European journal of pharmacology Dec, 2009 | Pubmed ID: 19825372
Frontiers in research series: Neural, hormonal and renal interactions in long-term blood pressure control II. Introduction.
Clinical and experimental pharmacology & physiology Feb, 2010 | Pubmed ID: 19930420
Angiotensin II in experimental hyperdynamic sepsis.
Critical care (London, England) , 2009 | Pubmed ID: 19948019
The impact of experimental hypoperfusion on subsequent kidney function.
Intensive care medicine Mar, 2010 | Pubmed ID: 20049587
Response of cardiac sympathetic nerve activity to intravenous irbesartan in heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology Apr, 2010 | Pubmed ID: 20147604
Early and sustained systemic and renal hemodynamic effects of intravenous radiocontrast.
Blood purification , 2010 | Pubmed ID: 20357433
Hypertonic sodium resuscitation after hemorrhage improves hemodynamic function by stimulating cardiac, but not renal, sympathetic nerve activity.
American journal of physiology. Heart and circulatory physiology Feb, 2011 | Pubmed ID: 21148761
The impact of intrarenal nitric oxide synthase inhibition on renal blood flow and function in mild and severe hyperdynamic sepsis.
Critical care medicine Apr, 2011 | Pubmed ID: 21169816
Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK.
European journal of pharmacology May, 2011 | Pubmed ID: 21371449
Renal bioenergetics during early gram-negative mammalian sepsis and angiotensin II infusion.
Intensive care medicine May, 2012 | Pubmed ID: 22302028
Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure.
Hypertension (Dallas, Tex. : 1979) Mar, 2012 | Pubmed ID: 22311902
The effects of terlipressin on regional hemodynamics and kidney function in experimental hyperdynamic sepsis.
PloS one , 2012 | Pubmed ID: 22355305
The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep.
The Journal of physiology Jan, 2013 | Pubmed ID: 22615431
Effect of selective inhibition of renal inducible nitric oxide synthase on renal blood flow and function in experimental hyperdynamic sepsis.
Critical care medicine Aug, 2012 | Pubmed ID: 22622397
Pulmonary Artery Catheter (PAC) Accuracy and Efficacy Compared with Flow Probe and Transcutaneous Doppler (USCOM): An Ovine Cardiac Output Validation.
Critical care research and practice , 2012 | Pubmed ID: 22649718
Novel targets for sepsis-induced kidney injury: the glomerular arterioles and the sympathetic nervous system.
Experimental physiology Nov, 2012 | Pubmed ID: 22689445
Cardiac sympathoexcitation in heart failure.
Autonomic neuroscience : basic & clinical Apr, 2013 | Pubmed ID: 23332860
Organ selective regulation of sympathetic outflow by the brain Angiotensin system.
Current hypertension reports Aug, 2013 | Pubmed ID: 23681510
Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.
The Biochemical journal Dec, 2013 | Pubmed ID: 24032640
Renal histopathology during experimental septic acute kidney injury and recovery.
Critical care medicine Jan, 2014 | Pubmed ID: 24126439
Intracarotid hypertonic sodium chloride differentially modulates sympathetic nerve activity to the heart and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology Apr, 2014 | Pubmed ID: 24523342
Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Mar, 2014 | Pubmed ID: 24588433
Glomerular haemodynamics, the renal sympathetic nervous system and sepsis-induced acute kidney injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Dec, 2014 | Pubmed ID: 24619060
Effects of renal denervation on regional hemodynamics and kidney function in experimental hyperdynamic sepsis.
Critical care medicine Jun, 2014 | Pubmed ID: 24670939
Role of prostaglandins in determining the increased cardiac sympathetic nerve activity in ovine sepsis.
American journal of physiology. Regulatory, integrative and comparative physiology Jul, 2014 | Pubmed ID: 24789991
Central exogenous nitric oxide decreases cardiac sympathetic drive and improves baroreflex control of heart rate in ovine heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology Aug, 2014 | Pubmed ID: 24848361
Tonic arterial chemoreceptor activity contributes to cardiac sympathetic activation in mild ovine heart failure.
Experimental physiology Aug, 2014 | Pubmed ID: 24928955
The low frequency power of heart rate variability is neither a measure of cardiac sympathetic tone nor of baroreflex sensitivity.
American journal of physiology. Heart and circulatory physiology Oct, 2014 | Pubmed ID: 25063795
Reinnervation of renal afferent and efferent nerves at 5.5 and 11 months after catheter-based radiofrequency renal denervation in sheep.
Hypertension (Dallas, Tex. : 1979) Feb, 2015 | Pubmed ID: 25403610
Effects of selective β1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis.
Critical care (London, England) Nov, 2014 | Pubmed ID: 25413250
Reply to "Letter to the editor: Does low-frequency power of heart rate variability correlate with cardiac sympathetic tone in normal sheep?".
American journal of physiology. Heart and circulatory physiology Jan, 2015 | Pubmed ID: 25552630
Reinnervation following catheter-based radio-frequency renal denervation.
Experimental physiology Apr, 2015 | Pubmed ID: 25573386
Long-term measurement of renal cortical and medullary tissue oxygenation and perfusion in unanesthetized sheep.
American journal of physiology. Regulatory, integrative and comparative physiology May, 2015 | Pubmed ID: 25761701
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol.
European journal of pharmacology Jul, 2015 | Pubmed ID: 25820159
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Critical care medicine Jul, 2015 | Pubmed ID: 25860204
Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury.
Critical care medicine Oct, 2015 | Pubmed ID: 26181218
Acid-base changes after fluid bolus: sodium chloride vs. sodium octanoate.
Intensive care medicine experimental Dec, 2013 | Pubmed ID: 26266792
Systemic and renal hemodynamic effects of intra-arterial radiocontrast.
Intensive care medicine experimental Dec, 2014 | Pubmed ID: 26266929
Variable responses of regional renal oxygenation and perfusion to vasoactive agents in awake sheep.
American journal of physiology. Regulatory, integrative and comparative physiology Nov, 2015 | Pubmed ID: 26354843
Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology Jan, 2016 | Pubmed ID: 26468257
The role of the renal afferent and efferent nerve fibers in heart failure.
Frontiers in physiology , 2015 | Pubmed ID: 26483699
Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity.
Nature biotechnology Mar, 2016 | Pubmed ID: 26854476
Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury.
Kidney international Jul, 2016 | Pubmed ID: 27165831
Chronic impedance spectroscopy of an endovascular stent-electrode array.
Journal of neural engineering 08, 2016 | Pubmed ID: 27378157
Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage.
Journal of the American College of Cardiology Feb, 2017 | Pubmed ID: 28231948
Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.
American journal of physiology. Heart and circulatory physiology May, 2017 | Pubmed ID: 28364017
An ovine model of cerebral catheter venography for implantation of an endovascular neural interface.
Journal of neurosurgery 04, 2018 | Pubmed ID: 28452616
The ovine motor cortex: A review of functional mapping and cytoarchitecture.
Neuroscience and biobehavioral reviews Sep, 2017 | Pubmed ID: 28595827
Circumventing a broken heart: cytokines and the subfornical organ.
American journal of physiology. Heart and circulatory physiology 10, 2017 | Pubmed ID: 28778916
Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic Acute Kidney Injury.
Critical care medicine 01, 2018 | Pubmed ID: 29077618
Differential effects of isotonic and hypotonic 4% albumin solution on intracranial pressure and renal perfusion and function.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Mar, 2018 | Pubmed ID: 29458321
An Ovine Model for Studying the Pathophysiology of Septic Acute Kidney Injury.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29468594
Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
Shock (Augusta, Ga.) 03, 2019 | Pubmed ID: 29489737
Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension.
Frontiers in medicine , 2018 | Pubmed ID: 29651418
Mechanisms underlying the increased cardiac norepinephrine spillover in heart failure.
American journal of physiology. Heart and circulatory physiology 08, 2018 | Pubmed ID: 29701999
Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure.
Heart, lung & circulation Nov, 2018 | Pubmed ID: 29703647
Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable.
Scientific reports 05, 2018 | Pubmed ID: 29849104
Sepsis-induced acute kidney injury: A disease of the microcirculation.
Microcirculation (New York, N.Y. : 1994) 02, 2019 | Pubmed ID: 29908046
Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 10, 2018 | Pubmed ID: 29974287
Increased cardiac sympathetic nerve activity in ovine heart failure is reduced by lesion of the area postrema, but not lamina terminalis.
Basic research in cardiology 08, 2018 | Pubmed ID: 30076468
Alterations in regional kidney oxygenation during expansion of extracellular fluid volume in conscious healthy sheep.
American journal of physiology. Regulatory, integrative and comparative physiology 12, 2018 | Pubmed ID: 30332304
In renovascular hypertension, TNF-α type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure.
Cardiovascular research 05, 2019 | Pubmed ID: 30358805
Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury.
Critical care medicine 01, 2019 | Pubmed ID: 30394921
Author Correction: Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable.
Scientific reports Nov, 2018 | Pubmed ID: 30478430
Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation.
Hypertension (Dallas, Tex. : 1979) 03, 2019 | Pubmed ID: 30661475
Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep.
British journal of anaesthesia Mar, 2019 | Pubmed ID: 30770052
Renal Cortical Perfusion, Measured by Superb Microvascular Imaging, during Infusion of Norepinephrine in Experimental Cardiopulmonary Bypass.
American journal of respiratory and critical care medicine 06, 2019 | Pubmed ID: 30785769
Carotid artery and cerebral blood flow during experimental cardiopulmonary resuscitation: A systematic review of the literature.
Resuscitation 05, 2019 | Pubmed ID: 30797862
Strategies that improve renal medullary oxygenation during experimental cardiopulmonary bypass may mitigate postoperative acute kidney injury.
Kidney international 06, 2019 | Pubmed ID: 31005272
Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent.
Nature biomedical engineering 12, 2018 | Pubmed ID: 31015727
Factors that confound the prediction of renal medullary oxygenation and risk of acute kidney injury from measurement of bladder urine oxygen tension.
Acta physiologica (Oxford, England) 09, 2019 | Pubmed ID: 31066975
Furosemide reverses medullary tissue hypoxia in ovine septic acute kidney injury.
American journal of physiology. Regulatory, integrative and comparative physiology 08, 2019 | Pubmed ID: 31141418
Blunted diuretic and natriuretic responses to acute sodium loading early after catheter-based renal denervation in normotensive sheep.
American journal of physiology. Regulatory, integrative and comparative physiology 08, 2019 | Pubmed ID: 31166691
Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.
Journal of the American College of Cardiology 06, 2019 | Pubmed ID: 31196459
Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology 09, 2019 | Pubmed ID: 31241978
Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock.
Blood purification , 2019 | Pubmed ID: 31336370
Intrathecal Administration of Losartan Reduces Directly Recorded Cardiac Sympathetic Nerve Activity in Ovine Heart Failure.
Hypertension (Dallas, Tex. : 1979) 10, 2019 | Pubmed ID: 31378100
Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation.
Frontiers in physiology , 2019 | Pubmed ID: 31427987
Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury.
Kidney international 11, 2019 | Pubmed ID: 31530477
Renal hemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep under total intravenous anesthesia.
American journal of physiology. Regulatory, integrative and comparative physiology 02, 2020 | Pubmed ID: 31823674
Renal Medullary Hypoxia: A New Therapeutic Target for Septic Acute Kidney Injury?
Seminars in nephrology 11, 2019 | Pubmed ID: 31836037
Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 07, 2020 | Pubmed ID: 32060380
Systemic haemodynamic, renal perfusion and renal oxygenation responses to changes in inspired oxygen fraction during total intravenous or volatile anaesthesia.
British journal of anaesthesia 08, 2020 | Pubmed ID: 32563492
Sympathetic nerves control bacterial clearance.
Scientific reports 09, 2020 | Pubmed ID: 32929135
Beneficial Effects of Vasopressin Compared With Norepinephrine on Renal Perfusion, Oxygenation, and Function in Experimental Septic Acute Kidney Injury.
Critical care medicine 10, 2020 | Pubmed ID: 32931198
Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond.
American journal of physiology. Regulatory, integrative and comparative physiology 12, 2020 | Pubmed ID: 33074016
Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience.
Journal of neurointerventional surgery Feb, 2021 | Pubmed ID: 33115813
Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal.
Brain stimulation Jan-Feb, 2021 | Pubmed ID: 33217609
Influence of blood haemoglobin concentration on renal haemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep.
Acta physiologica (Oxford, England) 03, 2021 | Pubmed ID: 33222404
Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
Critical care medicine 02, 2021 | Pubmed ID: 33239507
Emerging benefits and drawbacks of α -adrenoceptor agonists in the management of sepsis and critical illness.
British journal of pharmacology 03, 2021 | Pubmed ID: 33450087
Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease.
Hypertension (Dallas, Tex. : 1979) 04, 2021 | Pubmed ID: 33641371
The authors reply.
Critical care medicine 04, 2021 | Pubmed ID: 33731636
Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model.
Journal of critical care 08, 2021 | Pubmed ID: 33794470
Dynamic responses of renal oxygenation at the onset of cardiopulmonary bypass in sheep and man.
Perfusion May, 2021 | Pubmed ID: 33977810
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19.
British journal of pharmacology 10, 2021 | Pubmed ID: 34061355
Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation.
Scientific reports 07, 2021 | Pubmed ID: 34285286
Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure.
Hypertension (Dallas, Tex. : 1979) Sep, 2021 | Pubmed ID: 34333989
Reversal of renal tissue hypoxia during experimental cardiopulmonary bypass in sheep by increased pump flow and arterial pressure.
Acta physiologica (Oxford, England) 04, 2021 | Pubmed ID: 34347356
Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice.
Journal of clinical medicine Aug, 2021 | Pubmed ID: 34501245
Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage.
Hypertension (Dallas, Tex. : 1979) Nov, 2021 | Pubmed ID: 34739764
Sebastian Bass-Stringer1,2,
Colleen J. Thomas2,3,
Clive N. May3,
Paul Gregorevic4,
Kate L. Weeks1,5,6,
Julie R. McMullen1,2,5,6,7
1, Baker Heart and Diabetes Institute,
2Department of Physiology, Anatomy and Microbiology, La Trobe University,
3Florey Institute of Neuroscience and Mental Health, University of Melbourne,
4Department of Physiology, Centre for Muscle Research (CMR), The University of Melbourne,
5Department of Diabetes, Central Clinical School, Monash University,
6Baker Department of Cardiometabolic Health, The University of Melbourne,
7Department of Physiology and Department of Medicine Alfred Hospital, Monash University
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