Wei Yang

Guangdong Lewwin Pharmaceutical Research Institute Co., Guangdong Engineering Research Center for Innovative Drug Evaluation and Research

Affiliated withGuangdong Engineering Research Center for Innovative Drug Evaluation and Research Duke University Medical Center Duke University School of Medicine

Research Area

MedicineNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 7	Year
Publication title	2022
Publication title	2023
Publication title	2023
Publication title	2023
Publication title	2024

Other Publications

Article	Year
Pharmacokinetics and biotransformation investigation in beagle dog of active compounds from naoxintong capsule. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 33227707	2021
Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 34239584	2021
Transient global cerebral ischemia induces a massive increase in protein sumoylation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 17565359	2008
Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. Biochemical and biophysical research communications\| PubMed ID: 18021742	2008
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 18167501	2008
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? Journal of neurochemistry\| PubMed ID: 18410505	2008
Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 19240742	2009
The endoplasmic reticulum and neurological diseases. Experimental neurology\| PubMed ID: 19616544	2009
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free radical biology & medicine\| PubMed ID: 19631268	2009
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Journal of proteome research\| PubMed ID: 22082260	2012
Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons. Journal of neurochemistry\| PubMed ID: 22891650	2012
Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. Cancer science\| PubMed ID: 23078246	2013
Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases. Journal of biomolecular screening\| PubMed ID: 23470489	2013
Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair... Fish & shellfish immunology\| PubMed ID: 24239597	2014
Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 24301296	2014
Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways. Stroke; a journal of cerebral circulation\| PubMed ID: 24569813	2014
Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories. Journal of psychiatry & neuroscience : JPN\| PubMed ID: 24690371	2014
SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. EMBO reports\| PubMed ID: 24891386	2014
SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases. Proteomics\| PubMed ID: 25236368	2015
Comparative genomics reveals insights into avian genome evolution and adaptation. Science (New York, N.Y.)\| PubMed ID: 25504712	2014
Long-term safety and efficacy of imatinib in pulmonary arterial hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 26210752	2015
mTOR and its tight regulation for iNKT cell development and effector function. Molecular immunology\| PubMed ID: 26253278	2015
O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26661187	2016
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27217380	2017
Unfolded protein response in brain ischemia: A timely update. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27733676	2016
Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. Neuroscience\| PubMed ID: 27919694	2017
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G. Stroke\| PubMed ID: 28487326	2017
Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 28752781	2017
Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. Scientific reports\| PubMed ID: 28785061	2017
Targeting the SUMO pathway for neuroprotection in brain ischaemia. Stroke and vascular neurology\| PubMed ID: 28959470	2016
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29146736	2018
SUMOylation in brain ischemia: Patterns, targets, and translational implications. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 29148315	2018
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice. Aging and disease\| PubMed ID: 29392079	2018
Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 29472640	2018
Esophageal cancer in elderly patients: a population-based study. Journal of thoracic disease\| PubMed ID: 29600077	2018
High-speed widefield photoacoustic microscopy of small-animal hemodynamics. Biomedical optics express\| PubMed ID: 30319896	2018
Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice. Journal of the American Heart Association\| PubMed ID: 30371162	2018
Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research. Neurochemistry international\| PubMed ID: 30599146	2019
The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Human molecular genetics\| PubMed ID: 30689861	2019
The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications. Current issues in molecular biology\| PubMed ID: 31422937	2020
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. Experimental neurology\| PubMed ID: 31962128	2020
PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis. Stroke\| PubMed ID: 32212900	2020
SUMO1 Deficiency Exacerbates Neurological and Cardiac Dysfunction after Intracerebral Hemorrhage in Aged Mice. Translational stroke research\| PubMed ID: 32761461	2021
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 32787543	2021
MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation. Journal of neuroinflammation\| PubMed ID: 32867797	2020
Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32910521	2020
Phase-specific manipulation of neuronal activity: a promising stroke therapy approach. Neural regeneration research\| PubMed ID: 33318438	2021
Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke. Experimental neurology\| PubMed ID: 33600817	2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy\| PubMed ID: 33634751	2021
SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ. Frontiers in immunology\| PubMed ID: 33679811	2021
Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation. Journal of the American Heart Association\| PubMed ID: 34013738	2021
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. Journal of the American Heart Association\| PubMed ID: 34111943	2021
Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice. Shock (Augusta, Ga.)\| PubMed ID: 34652341	2021
An update on the unfolded protein response in brain ischemia: Experimental evidence and therapeutic opportunities. Neurochemistry international\| PubMed ID: 34732355	2021
Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 35131154	2022
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke. Journal of neuroinflammation\| PubMed ID: 35392936	2022
Targeting O-GlcNAcylation in ischemic stroke. Neural regeneration research\| PubMed ID: 35535885	2022
Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke. Frontiers in cellular neuroscience\| PubMed ID: 36313623	2022
Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice. Communications biology\| PubMed ID: 36894627	2023
Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study. Journal of the American Heart Association\| PubMed ID: 25896890	2015
Acid Load and Phosphorus Homeostasis in CKD. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 28645705	2017
Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 31668375	2020
Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside. Journal of biophotonics\| PubMed ID: 33768709	2021
Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 34052355	2022
Race, Genetic Ancestry, and Estimating Kidney Function in CKD. The New England journal of medicine\| PubMed ID: 34554660	2021
High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner. Photoacoustics\| PubMed ID: 34956833	2021
A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise. Journal of clinical monitoring and computing\| PubMed ID: 35040037	2022
A Comparative Study of Serum Phosphate and Related Parameters in Chronic Kidney Disease between the USA and Japan. American journal of nephrology\| PubMed ID: 35226897	2022
Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications. Circulation research\| PubMed ID: 35420912	2022
High-speed wide-field photoacoustic microscopy using a cylindrically focused transparent high-frequency ultrasound transducer. Photoacoustics\| PubMed ID: 36299642	2022
Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke. Frontiers in neuroscience\| PubMed ID: 36532279	2022
Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT). Photoacoustics\| PubMed ID: 36620854	2023
[Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica\| PubMed ID: 29600631	2018
Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29794465	2018
Neuronal Apoptosis Preventive Potential of Sophocarpine via Suppression of Aβ-Accumulation and Down-Regulation of Inflammatory Response. Doklady. Biochemistry and biophysics\| PubMed ID: 33895927	2021
A randomized, double-blind, single-dose, single-center, parallel phase I clinical study comparing the pharmacokinetics, immunogenicity, safety, and tolerance of pertuzumab injection and Perj... Expert opinion on biological therapy\| PubMed ID: 34607519	2022
A randomized, open-label, single-dose, two-cycle crossover study to evaluate the bioequivalence and safety of lenvatinib and Lenvima® in Chinese healthy subjects. Expert opinion on investigational drugs\| PubMed ID: 35427205	2022
A randomized, double-blind, single-dose, parallel phase I clinical trial to compare the bioequivalence, immunogenicity, and safety of bevacizumab biosimilar and bevacizumab in healthy Chines... Expert opinion on drug metabolism & toxicology\| PubMed ID: 35961948	2022
Pharmacokinetics and safety of dasatinib and its generic: a phase I bioequivalence study in healthy Chinese subjects. Expert opinion on investigational drugs\| PubMed ID: 36757390	2023
Comparing the bioequivalence and safety of liraglutide in healthy Chinese subjects: an open, single-dose, randomized, repeated, two-sequence, two-cycle phase I clinical trial. Expert review of clinical pharmacology\| PubMed ID: 36883362	2023
Bibliometric analysis of acupuncture and moxibustion treatment for mild cognitive impairment. Frontiers in neuroscience\| PubMed ID: 37397443	2023
Exploring the therapeutic mechanism of Banxia Xiexin Decoction in mild cognitive impairment and diabetes mellitus: a network pharmacology approach. Metabolic brain disease\| PubMed ID: 37556042	2023
Analysis of influencing factors on long COVID in COVID-19 patients infected with omicron variant three months after discharge: a cross-sectional study. BMC infectious diseases\| PubMed ID: 38166694	2024
[Technical specifications for intensive hospital safety monitoring of post-marketing Chinese medicine (draft version for comments)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica\| PubMed ID: 24471304	2013
Three-dimensional, biomimetic electrospun scaffolds reinforced with carbon nanotubes for temporomandibular joint disc regeneration. Acta biomaterialia\| PubMed ID: 35562008	2022
NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology\| PubMed ID: 36592742	2022
TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage. Journal of translational medicine\| PubMed ID: 37798747	2023
Targeted Delivery of Gemcitabine for Precision Therapy of Cholangiocarcinoma Using Hyaluronic Acid-Modified Metal-Organic Framework Nanoparticles. ACS omega\| PubMed ID: 38496964	2024
Splenic SUMO1 controls systemic inflammation in experimental sepsis. Frontiers in immunology\| PubMed ID: 37520526	2023
Positioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma. Frontiers in cell and developmental biology\| PubMed ID: 37860820	2023
Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 38543139	2024