Guangdong Lewwin Pharmaceutical Research Institute Co.,
Ltd.,
Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research,
TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine,
Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine
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Pharmacokinetics and biotransformation investigation in beagle dog of active compounds from naoxintong capsule.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Jan, 2021 | Pubmed ID: 33227707
Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin.
Evidence-based complementary and alternative medicine : eCAM , 2021 | Pubmed ID: 34239584
Transient global cerebral ischemia induces a massive increase in protein sumoylation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2008 | Pubmed ID: 17565359
Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter.
Biochemical and biophysical research communications Jan, 2008 | Pubmed ID: 18021742
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2008 | Pubmed ID: 18167501
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?
Journal of neurochemistry Aug, 2008 | Pubmed ID: 18410505
Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2009 | Pubmed ID: 19240742
The endoplasmic reticulum and neurological diseases.
Experimental neurology Oct, 2009 | Pubmed ID: 19616544
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.
Free radical biology & medicine Oct, 2009 | Pubmed ID: 19631268
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Journal of proteome research Feb, 2012 | Pubmed ID: 22082260
Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.
Journal of neurochemistry Nov, 2012 | Pubmed ID: 22891650
Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.
Cancer science Jan, 2013 | Pubmed ID: 23078246
Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.
Journal of biomolecular screening Jun, 2013 | Pubmed ID: 23470489
Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells.
Fish & shellfish immunology Jan, 2014 | Pubmed ID: 24239597
Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2014 | Pubmed ID: 24301296
Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.
Stroke; a journal of cerebral circulation Apr, 2014 | Pubmed ID: 24569813
Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.
Journal of psychiatry & neuroscience : JPN Jul, 2014 | Pubmed ID: 24690371
SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development.
EMBO reports Aug, 2014 | Pubmed ID: 24891386
SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.
Proteomics Mar, 2015 | Pubmed ID: 25236368
Comparative genomics reveals insights into avian genome evolution and adaptation.
Science (New York, N.Y.) Dec, 2014 | Pubmed ID: 25504712
Long-term safety and efficacy of imatinib in pulmonary arterial hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Nov, 2015 | Pubmed ID: 26210752
mTOR and its tight regulation for iNKT cell development and effector function.
Molecular immunology Dec, 2015 | Pubmed ID: 26253278
O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2016 | Pubmed ID: 26661187
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2017 | Pubmed ID: 27217380
Unfolded protein response in brain ischemia: A timely update.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Dec, 2016 | Pubmed ID: 27733676
Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.
Neuroscience Feb, 2017 | Pubmed ID: 27919694
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.
Stroke Jun, 2017 | Pubmed ID: 28487326
Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Oct, 2017 | Pubmed ID: 28752781
Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.
Scientific reports Aug, 2017 | Pubmed ID: 28785061
Targeting the SUMO pathway for neuroprotection in brain ischaemia.
Stroke and vascular neurology Sep, 2016 | Pubmed ID: 28959470
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2018 | Pubmed ID: 29146736
SUMOylation in brain ischemia: Patterns, targets, and translational implications.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jan, 2018 | Pubmed ID: 29148315
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.
Aging and disease Feb, 2018 | Pubmed ID: 29392079
Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.
Laboratory investigation; a journal of technical methods and pathology Jun, 2018 | Pubmed ID: 29472640
Esophageal cancer in elderly patients: a population-based study.
Journal of thoracic disease Jan, 2018 | Pubmed ID: 29600077
High-speed widefield photoacoustic microscopy of small-animal hemodynamics.
Biomedical optics express Oct, 2018 | Pubmed ID: 30319896
Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.
Journal of the American Heart Association 09, 2018 | Pubmed ID: 30371162
Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.
Neurochemistry international Jul, 2019 | Pubmed ID: 30599146
The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.
Human molecular genetics May, 2019 | Pubmed ID: 30689861
The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.
Current issues in molecular biology , 2020 | Pubmed ID: 31422937
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.
Experimental neurology Apr, 2020 | Pubmed ID: 31962128
PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.
Stroke May, 2020 | Pubmed ID: 32212900
SUMO1 Deficiency Exacerbates Neurological and Cardiac Dysfunction after Intracerebral Hemorrhage in Aged Mice.
Translational stroke research Aug, 2021 | Pubmed ID: 32761461
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2021 | Pubmed ID: 32787543
MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.
Journal of neuroinflammation Aug, 2020 | Pubmed ID: 32867797
Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2020 | Pubmed ID: 32910521
Phase-specific manipulation of neuronal activity: a promising stroke therapy approach.
Neural regeneration research Jul, 2021 | Pubmed ID: 33318438
Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.
Experimental neurology May, 2021 | Pubmed ID: 33600817
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy Feb, 2021 | Pubmed ID: 33634751
SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ.
Frontiers in immunology , 2021 | Pubmed ID: 33679811
Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.
Journal of the American Heart Association Jun, 2021 | Pubmed ID: 34013738
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.
Journal of the American Heart Association Jun, 2021 | Pubmed ID: 34111943
Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.
Shock (Augusta, Ga.) Nov, 2021 | Pubmed ID: 34652341
An update on the unfolded protein response in brain ischemia: Experimental evidence and therapeutic opportunities.
Neurochemistry international Dec, 2021 | Pubmed ID: 34732355
Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy.
Neuromodulation : journal of the International Neuromodulation Society Apr, 2022 | Pubmed ID: 35131154
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.
Journal of neuroinflammation Apr, 2022 | Pubmed ID: 35392936
Targeting O-GlcNAcylation in ischemic stroke.
Neural regeneration research Nov, 2022 | Pubmed ID: 35535885
Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke.
Frontiers in cellular neuroscience , 2022 | Pubmed ID: 36313623
Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.
Communications biology Mar, 2023 | Pubmed ID: 36894627
Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study.
Journal of the American Heart Association Apr, 2015 | Pubmed ID: 25896890
Acid Load and Phosphorus Homeostasis in CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation Oct, 2017 | Pubmed ID: 28645705
Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation Feb, 2020 | Pubmed ID: 31668375
Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.
Journal of biophotonics Jul, 2021 | Pubmed ID: 33768709
Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation Jan, 2022 | Pubmed ID: 34052355
Race, Genetic Ancestry, and Estimating Kidney Function in CKD.
The New England journal of medicine Nov, 2021 | Pubmed ID: 34554660
High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner.
Photoacoustics Dec, 2021 | Pubmed ID: 34956833
A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise.
Journal of clinical monitoring and computing Oct, 2022 | Pubmed ID: 35040037
A Comparative Study of Serum Phosphate and Related Parameters in Chronic Kidney Disease between the USA and Japan.
American journal of nephrology , 2022 | Pubmed ID: 35226897
Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications.
Circulation research Apr, 2022 | Pubmed ID: 35420912
High-speed wide-field photoacoustic microscopy using a cylindrically focused transparent high-frequency ultrasound transducer.
Photoacoustics Dec, 2022 | Pubmed ID: 36299642
Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.
Frontiers in neuroscience , 2022 | Pubmed ID: 36532279
Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT).
Photoacoustics Feb, 2023 | Pubmed ID: 36620854
[Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Feb, 2018 | Pubmed ID: 29600631
Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2018 | Pubmed ID: 29794465
Neuronal Apoptosis Preventive Potential of Sophocarpine via Suppression of Aβ-Accumulation and Down-Regulation of Inflammatory Response.
Doklady. Biochemistry and biophysics Mar, 2021 | Pubmed ID: 33895927
A randomized, double-blind, single-dose, single-center, parallel phase I clinical study comparing the pharmacokinetics, immunogenicity, safety, and tolerance of pertuzumab injection and Perjeta® in healthy Chinese male subjects.
Expert opinion on biological therapy Feb, 2022 | Pubmed ID: 34607519
A randomized, open-label, single-dose, two-cycle crossover study to evaluate the bioequivalence and safety of lenvatinib and Lenvima® in Chinese healthy subjects.
Expert opinion on investigational drugs Jul, 2022 | Pubmed ID: 35427205
A randomized, double-blind, single-dose, parallel phase I clinical trial to compare the bioequivalence, immunogenicity, and safety of bevacizumab biosimilar and bevacizumab in healthy Chinese subjects.
Expert opinion on drug metabolism & toxicology , 2022 | Pubmed ID: 35961948
Pharmacokinetics and safety of dasatinib and its generic: a phase I bioequivalence study in healthy Chinese subjects.
Expert opinion on investigational drugs Mar, 2023 | Pubmed ID: 36757390
Comparing the bioequivalence and safety of liraglutide in healthy Chinese subjects: an open, single-dose, randomized, repeated, two-sequence, two-cycle phase I clinical trial.
Expert review of clinical pharmacology Apr, 2023 | Pubmed ID: 36883362
Bibliometric analysis of acupuncture and moxibustion treatment for mild cognitive impairment.
Frontiers in neuroscience , 2023 | Pubmed ID: 37397443
Exploring the therapeutic mechanism of Banxia Xiexin Decoction in mild cognitive impairment and diabetes mellitus: a network pharmacology approach.
Metabolic brain disease Oct, 2023 | Pubmed ID: 37556042
Analysis of influencing factors on long COVID in COVID-19 patients infected with omicron variant three months after discharge: a cross-sectional study.
BMC infectious diseases Jan, 2024 | Pubmed ID: 38166694
[Technical specifications for intensive hospital safety monitoring of post-marketing Chinese medicine (draft version for comments)].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Sep, 2013 | Pubmed ID: 24471304
Three-dimensional, biomimetic electrospun scaffolds reinforced with carbon nanotubes for temporomandibular joint disc regeneration.
Acta biomaterialia Jul, 2022 | Pubmed ID: 35562008
NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Dec, 2022 | Pubmed ID: 36592742
TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage.
Journal of translational medicine Oct, 2023 | Pubmed ID: 37798747
Targeted Delivery of Gemcitabine for Precision Therapy of Cholangiocarcinoma Using Hyaluronic Acid-Modified Metal-Organic Framework Nanoparticles.
ACS omega Mar, 2024 | Pubmed ID: 38496964
Splenic SUMO1 controls systemic inflammation in experimental sepsis.
Frontiers in immunology , 2023 | Pubmed ID: 37520526
Positioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma.
Frontiers in cell and developmental biology , 2023 | Pubmed ID: 37860820
Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke.
Pharmaceuticals (Basel, Switzerland) Mar, 2024 | Pubmed ID: 38543139
Limei Wang1,
Jianmin Guo1,
Xiaoman Zhong1,
Jian Zhang2,
Yali Sheng1,
Qiwen Lai1,
Hui Song1,
Wei Yang1
1Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research,
2Department of Biomedical Engineering, School of Basic Medical Sciences, the Sixth Affiliated Hospital of Guangzhou Medical University
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