Wei Yang

Pharmacokinetics and biotransformation investigation in beagle dog of active compounds from naoxintong capsule.

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin.

Transient global cerebral ischemia induces a massive increase in protein sumoylation.

Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter.

Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.

Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?

Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.

The endoplasmic reticulum and neurological diseases.

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.

Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.

Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.

Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.

Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells.

Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.

Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.

Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.

SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development.

SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.

Comparative genomics reveals insights into avian genome evolution and adaptation.

Long-term safety and efficacy of imatinib in pulmonary arterial hypertension.

mTOR and its tight regulation for iNKT cell development and effector function.

O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.

Unfolded protein response in brain ischemia: A timely update.

Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.

XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.

Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis.

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

Targeting the SUMO pathway for neuroprotection in brain ischaemia.

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

SUMOylation in brain ischemia: Patterns, targets, and translational implications.

Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.

Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.

Esophageal cancer in elderly patients: a population-based study.

High-speed widefield photoacoustic microscopy of small-animal hemodynamics.

Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.

Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.

The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.

The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.

Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.

PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.

SUMO1 Deficiency Exacerbates Neurological and Cardiac Dysfunction after Intracerebral Hemorrhage in Aged Mice.

Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression.

MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.

Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.

Phase-specific manipulation of neuronal activity: a promising stroke therapy approach.

Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ.

Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.

Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.

Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.

An update on the unfolded protein response in brain ischemia: Experimental evidence and therapeutic opportunities.

Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy.

Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.

Targeting O-GlcNAcylation in ischemic stroke.

Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke.

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.

Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study.

Acid Load and Phosphorus Homeostasis in CKD.

Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.

Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.

Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.

Race, Genetic Ancestry, and Estimating Kidney Function in CKD.

High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner.

A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise.

A Comparative Study of Serum Phosphate and Related Parameters in Chronic Kidney Disease between the USA and Japan.

Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications.

High-speed wide-field photoacoustic microscopy using a cylindrically focused transparent high-frequency ultrasound transducer.

Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.

Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT).

[Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease].

Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy.

Neuronal Apoptosis Preventive Potential of Sophocarpine via Suppression of Aβ-Accumulation and Down-Regulation of Inflammatory Response.

A randomized, double-blind, single-dose, single-center, parallel phase I clinical study comparing the pharmacokinetics, immunogenicity, safety, and tolerance of pertuzumab injection and Perjeta® in healthy Chinese male subjects.

A randomized, open-label, single-dose, two-cycle crossover study to evaluate the bioequivalence and safety of lenvatinib and Lenvima® in Chinese healthy subjects.

A randomized, double-blind, single-dose, parallel phase I clinical trial to compare the bioequivalence, immunogenicity, and safety of bevacizumab biosimilar and bevacizumab in healthy Chinese subjects.

Pharmacokinetics and safety of dasatinib and its generic: a phase I bioequivalence study in healthy Chinese subjects.

Comparing the bioequivalence and safety of liraglutide in healthy Chinese subjects: an open, single-dose, randomized, repeated, two-sequence, two-cycle phase I clinical trial.

Bibliometric analysis of acupuncture and moxibustion treatment for mild cognitive impairment.

Exploring the therapeutic mechanism of Banxia Xiexin Decoction in mild cognitive impairment and diabetes mellitus: a network pharmacology approach.

Analysis of influencing factors on long COVID in COVID-19 patients infected with omicron variant three months after discharge: a cross-sectional study.

[Technical specifications for intensive hospital safety monitoring of post-marketing Chinese medicine (draft version for comments)].

Three-dimensional, biomimetic electrospun scaffolds reinforced with carbon nanotubes for temporomandibular joint disc regeneration.

NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP.

TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage.

Targeted Delivery of Gemcitabine for Precision Therapy of Cholangiocarcinoma Using Hyaluronic Acid-Modified Metal-Organic Framework Nanoparticles.

Splenic SUMO1 controls systemic inflammation in experimental sepsis.

Positioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma.

Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke.