Cardiovascular Division
Elena Aikawa has not added Biography.
If you are Elena Aikawa and would like to personalize this page please email our Author Liaison for assistance.
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation Jul, 2005 | Pubmed ID: 16043658
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Circulation Oct, 2005 | Pubmed ID: 16203910
Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques.
Circulation Oct, 2005 | Pubmed ID: 16230484
Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.
Circulation Mar, 2006 | Pubmed ID: 16534030
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
Journal of biomedical optics Mar-Apr, 2006 | Pubmed ID: 16674184
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Circulation May, 2006 | Pubmed ID: 16682613
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.
Circulation Jul, 2006 | Pubmed ID: 16801460
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16801531
Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials.
Molecular imaging Apr-Jun, 2006 | Pubmed ID: 16954022
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.
Circulation research Oct, 2006 | Pubmed ID: 16973908
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.
Circulation Oct, 2006 | Pubmed ID: 17000904
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.
The Journal of clinical investigation Jan, 2007 | Pubmed ID: 17200719
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.
Circulation Jan, 2007 | Pubmed ID: 17224478
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo.
Circulation Mar, 2007 | Pubmed ID: 17339546
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.
Circulation research Apr, 2007 | Pubmed ID: 17379832
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.
Circulation May, 2007 | Pubmed ID: 17420353
Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology Sep-Oct, 2007 | Pubmed ID: 17868878
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
The Journal of experimental medicine Nov, 2007 | Pubmed ID: 18025128
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation Dec, 2007 | Pubmed ID: 18040026
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.
Circulation Jan, 2008 | Pubmed ID: 18158358
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain : a journal of neurology Apr, 2008 | Pubmed ID: 18234693
Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.
Circulation Mar, 2008 | Pubmed ID: 18268141
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.
European heart journal Feb, 2008 | Pubmed ID: 18276618
Simplified syntheses of complex multifunctional nanomaterials.
Chemical communications (Cambridge, England) Oct, 2008 | Pubmed ID: 18830495
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.
Circulation Oct, 2008 | Pubmed ID: 18852366
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2008 | Pubmed ID: 19011099
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19015534
Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II.
Laboratory investigation; a journal of technical methods and pathology Mar, 2009 | Pubmed ID: 19153555
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
NeuroImage Apr, 2009 | Pubmed ID: 19154791
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Circulation Apr, 2009 | Pubmed ID: 19307473
Molecular imaging of innate immune cell function in transplant rejection.
Circulation Apr, 2009 | Pubmed ID: 19332470
The antiproliferative cytostatic effects of a self-activating viridin prodrug.
Molecular cancer therapeutics Jun, 2009 | Pubmed ID: 19509266
Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation.
Circulation Jul, 2009 | Pubmed ID: 19597052
Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.
Arteriosclerosis, thrombosis, and vascular biology Oct, 2009 | Pubmed ID: 19608968
Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages.
Arteriosclerosis, thrombosis, and vascular biology Oct, 2009 | Pubmed ID: 19644051
Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
Science (New York, N.Y.) Jul, 2009 | Pubmed ID: 19644120
Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.
Tissue engineering. Part A Jan, 2010 | Pubmed ID: 19698056
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.
Tissue engineering. Part C, Methods Aug, 2010 | Pubmed ID: 19751103
Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium.
Circulation. Cardiovascular imaging May, 2009 | Pubmed ID: 19808594
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.
Journal of the American Chemical Society Nov, 2009 | Pubmed ID: 19817443
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.
JACC. Cardiovascular imaging Oct, 2009 | Pubmed ID: 19833312
Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.
Circulation. Cardiovascular imaging Nov, 2009 | Pubmed ID: 19920044
Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.
Circulation. Cardiovascular imaging Nov, 2009 | Pubmed ID: 19920045
Notch signaling in cardiovascular disease and calcification.
Current cardiology reviews Aug, 2008 | Pubmed ID: 19936191
The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells.
Biomaterials Feb, 2010 | Pubmed ID: 19944458
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
Integrative biology : quantitative biosciences from nano to macro Apr, 2009 | Pubmed ID: 20023731
In vivo monitoring of function of autologous engineered pulmonary valve.
The Journal of thoracic and cardiovascular surgery Mar, 2010 | Pubmed ID: 20176213
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
Journal of the American College of Cardiology Apr, 2010 | Pubmed ID: 20378083
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.
European heart journal Aug, 2010 | Pubmed ID: 20601388
Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.
Arteriosclerosis, thrombosis, and vascular biology Oct, 2010 | Pubmed ID: 20689078
Mitral valve endothelial cells with osteogenic differentiation potential.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2011 | Pubmed ID: 21164078
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata.
European heart journal Nov, 2011 | Pubmed ID: 21292680
Cardiovascular calcification: an inflammatory disease.
Circulation journal : official journal of the Japanese Circulation Society , 2011 | Pubmed ID: 21566338
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.
Science translational medicine May, 2011 | Pubmed ID: 21613624
Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification.
Circulation research May, 2011 | Pubmed ID: 21617135
Progenitor cells confer plasticity to cardiac valve endothelium.
Journal of cardiovascular translational research Dec, 2011 | Pubmed ID: 21789724
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.
Nature medicine Sep, 2011 | Pubmed ID: 21857652
Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2011 | Pubmed ID: 21903941
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.
Circulation Oct, 2011 | Pubmed ID: 22007101
The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.
Endocrinology Dec, 2011 | Pubmed ID: 22009730
Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.
Radiology Jan, 2012 | Pubmed ID: 22084204
Look more closely at the valve: imaging calcific aortic valve disease.
Circulation Jan, 2012 | Pubmed ID: 22090164
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22123981
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2012 | Pubmed ID: 22223731
Cardiovascular inflammation.
International journal of inflammation , 2012 | Pubmed ID: 22518345
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2012 | Pubmed ID: 22699504
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
European heart journal Feb, 2013 | Pubmed ID: 22927557
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.
PLoS biology , 2012 | Pubmed ID: 23271954
Visualizing novel concepts of cardiovascular calcification.
Trends in cardiovascular medicine Apr, 2013 | Pubmed ID: 23290463
MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.
Circulation research Mar, 2013 | Pubmed ID: 23538277
Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation.
International journal of inflammation , 2013 | Pubmed ID: 23555068
Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.
Circulation research Jun, 2013 | Pubmed ID: 23616621
Elastogenesis at the onset of human cardiac valve development.
Development (Cambridge, England) Jun, 2013 | Pubmed ID: 23637335
Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis.
Journal of the American College of Cardiology Oct, 2013 | Pubmed ID: 23707315
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2013 | Pubmed ID: 23733926
Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification.
Arteriosclerosis, thrombosis, and vascular biology Aug, 2013 | Pubmed ID: 23766262
Medial and intimal calcification in chronic kidney disease: stressing the contributions.
Journal of the American Heart Association Oct, 2013 | Pubmed ID: 24060959
Cystathionine γ-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2014 | Pubmed ID: 24357058
Potential drug targets for calcific aortic valve disease.
Nature reviews. Cardiology Apr, 2014 | Pubmed ID: 24445487
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
PloS one , 2014 | Pubmed ID: 24595280
Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation.
Circulation research Mar, 2014 | Pubmed ID: 24677232
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Arteriosclerosis, thrombosis, and vascular biology Jul, 2014 | Pubmed ID: 24951650
Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform.
Advanced healthcare materials Jan, 2015 | Pubmed ID: 24958085
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.
Current opinion in lipidology Oct, 2014 | Pubmed ID: 25188916
Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2014 | Pubmed ID: 25189570
EVpedia: a community web portal for extracellular vesicles research.
Bioinformatics (Oxford, England) Mar, 2015 | Pubmed ID: 25388151
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.
Journal of extracellular vesicles , 2014 | Pubmed ID: 25491249
Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease.
The American journal of pathology Apr, 2015 | Pubmed ID: 25680278
Cardiovascular calcification: current controversies and novel concepts.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology Jul-Aug, 2015 | Pubmed ID: 25797772
International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013).
Journal of extracellular vesicles , 2013 | Pubmed ID: 26082318
A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease.
Circulation Aug, 2015 | Pubmed ID: 26224809
Valvular interstitial cells suppress calcification of valvular endothelial cells.
Atherosclerosis Sep, 2015 | Pubmed ID: 26232165
Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach.
Seminars in cell & developmental biology Oct, 2015 | Pubmed ID: 26358815
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
PloS one , 2015 | Pubmed ID: 26367531
Mitral valve disease--morphology and mechanisms.
Nature reviews. Cardiology Dec, 2015 | Pubmed ID: 26483167
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Nature materials Mar, 2016 | Pubmed ID: 26752654
Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
Journal of the American College of Cardiology Jan, 2016 | Pubmed ID: 26796392
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2016 | Pubmed ID: 26800565
Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
The Journal of physiology Jan, 2016 | Pubmed ID: 26824781
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
The Journal of clinical investigation Apr, 2016 | Pubmed ID: 26950419
3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
European heart journal cardiovascular Imaging May, 2016 | Pubmed ID: 26976355
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Journal of molecular and cellular cardiology May, 2016 | Pubmed ID: 26996755
Zooming in on the genesis of atherosclerotic plaque microcalcifications.
The Journal of physiology Apr, 2016 | Pubmed ID: 27040360
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Circulation research Jul, 2017 | Pubmed ID: 28607103
Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.
Circulation research Jun, 2017 | Pubmed ID: 28642321
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2018 | Pubmed ID: 29191923
Dimerization of sortilin regulates its trafficking to extracellular vesicles.
The Journal of biological chemistry Mar, 2018 | Pubmed ID: 29382723
Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.
International journal of molecular sciences Feb, 2018 | Pubmed ID: 29495441
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
Nanomaterials (Basel, Switzerland) May, 2018 | Pubmed ID: 29751516
Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.
Scientific reports Jun, 2018 | Pubmed ID: 29899496
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.
Nature reviews. Cardiology May, 2019 | Pubmed ID: 30531869
Complex association of lipoprotein(a) with aortic stenosis.
Heart (British Cardiac Society) May, 2020 | Pubmed ID: 32086294
Innate and adaptive immunity in cardiovascular calcification.
Atherosclerosis Aug, 2020 | Pubmed ID: 32222287
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Science advances Sep, 2020 | Pubmed ID: 32938681
ApoC-III is a novel inducer of calcification in human aortic valves.
The Journal of biological chemistry , 2021 | Pubmed ID: 33334888
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2021 | Pubmed ID: 33795519
Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.
Journal of the American Heart Association Oct, 2021 | Pubmed ID: 34632804
Controlled delivery of gold nanoparticle-coupled miRNA therapeutics an injectable self-healing hydrogel.
Nanoscale Dec, 2021 | Pubmed ID: 34817483
Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition.
Journal of the American Heart Association Apr, 2022 | Pubmed ID: 35348006
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Cell reports Apr, 2022 | Pubmed ID: 35417712
Elevated lipoprotein(a) as a predictor for coronary events in older men.
Journal of lipid research Aug, 2022 | Pubmed ID: 35724702
Caitlin O'Rourke*,1,
Georgia Shelton*,1,2,
Joshua D. Hutcheson3,4,
Megan F. Burke2,
Trejeeve Martyn1,
Timothy E. Thayer2,
Hannah R. Shakartzi1,
Mary D. Buswell1,
Robert E. Tainsh1,
Binglan Yu1,4,
Aranya Bagchi1,4,
David K. Rhee2,4,
Connie Wu1,2,4,
Matthias Derwall5,
Emmanuel S. Buys1,4,
Paul B. Yu3,4,
Kenneth D. Bloch1,2,4,
Elena Aikawa3,4,
Donald B. Bloch1,5,6,
Rajeev Malhotra2,4
1Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital,
2Cardiovascular Research Center and Cardiology Division of the Department of Medicine, Massachusetts General Hospital,
3Cardiovascular Division, Brigham and Women's Hospital,
4, Harvard Medical School,
5Department of Anesthesiology, Uniklinik RWTH Aachen, RWTH Aachen University,
6Center for Immunology and Inflammatory Diseases and the Division of Rheumatology, Allergy, and Immunology of the Department of Medicine, Massachusetts General Hospital
Rachel M. E. Cahalane*,1,2,
Mandy E. Turner*,1,
Cassandra L. Clift1,
Mark C. Blaser1,
Gabrielle Bogut1,
Sydney Levy1,
Taku Kasai1,
Tom A. P. Driedonks3,4,
Esther N. M. Nolte-‘t Hoen4,
Masanori Aikawa1,5,
Sasha A. Singh1,5,
Elena Aikawa1,5
1Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School,
2Mechanobiology and Medical Device Research Group (MMDRG), Biomedical Engineering, College of Science and Engineering, University of Galway,
3Department of CDL Research, University Medical Center Utrecht,
4Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University,
5Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
关于 JoVE
版权所属 © 2024 MyJoVE 公司版权所有,本公司不涉及任何医疗业务和医疗服务。