Elena Aikawa

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.

Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.

Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques.

Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.

Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.

Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.

Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.

Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials.

Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.

Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.

Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo.

Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.

Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.

Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep.

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.

Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.

Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.

Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.

Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.

Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.

Simplified syntheses of complex multifunctional nanomaterials.

Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.

Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.

Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II.

Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.

Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.

Molecular imaging of innate immune cell function in transplant rejection.

The antiproliferative cytostatic effects of a self-activating viridin prodrug.

Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation.

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.

Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages.

Identification of splenic reservoir monocytes and their deployment to inflammatory sites.

Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.

Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.

Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium.

Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.

18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.

Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.

Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.

Notch signaling in cardiovascular disease and calcification.

The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells.

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.

In vivo monitoring of function of autologous engineered pulmonary valve.

Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.

Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.

Mitral valve endothelial cells with osteogenic differentiation potential.

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata.

Cardiovascular calcification: an inflammatory disease.

Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.

Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification.

Progenitor cells confer plasticity to cardiac valve endothelium.

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.

Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis.

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.

Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.

Look more closely at the valve: imaging calcific aortic valve disease.

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.

Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis.

Cardiovascular inflammation.

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.

Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.

Visualizing novel concepts of cardiovascular calcification.

MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.

Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation.

Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.

Elastogenesis at the onset of human cardiac valve development.

Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis.

Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries.

Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification.

Medial and intimal calcification in chronic kidney disease: stressing the contributions.

Cystathionine γ-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis.

Potential drug targets for calcific aortic valve disease.

A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.

Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation.

Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.

Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform.

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

EVpedia: a community web portal for extracellular vesicles research.

Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.

Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease.

Cardiovascular calcification: current controversies and novel concepts.

International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013).

A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease.

Valvular interstitial cells suppress calcification of valvular endothelial cells.

Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach.

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.

Mitral valve disease--morphology and mechanisms.

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.

Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.

Zooming in on the genesis of atherosclerotic plaque microcalcifications.

Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.

Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.

Dimerization of sortilin regulates its trafficking to extracellular vesicles.

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.

Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.

Complex association of lipoprotein(a) with aortic stenosis.

Innate and adaptive immunity in cardiovascular calcification.

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.

ApoC-III is a novel inducer of calcification in human aortic valves.

Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.

Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics an injectable self-healing hydrogel.

Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition.

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.

Elevated lipoprotein(a) as a predictor for coronary events in older men.