Manikandan Paramasivam

Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation.

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins.

Triplex glue by synthesizing conjugated flexible intercalators.

Protein hnRNPA1 binds to a critical G-rich element of KRAS and unwinds G-quadruplex structures: implications in transcription.

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription.

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.

The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE.

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.

ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.

Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.

Nuclear GIT2 is an ATM substrate and promotes DNA repair.

UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.

Single Molecule Analysis of Laser Localized Interstrand Crosslinks.

Reconstitution of anaphase DNA bridge recognition and disjunction.

PICH and TOP3A cooperate to induce positive DNA supercoiling.