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Laboratory of Molecular Gerontology
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Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation.
Nucleic acids research Jun, 2008 | Pubmed ID: 18456705
Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins.
Nucleic acids research Jun, 2008 | Pubmed ID: 18490377
Triplex glue by synthesizing conjugated flexible intercalators.
Nucleic acids symposium series (2004) , 2008 | Pubmed ID: 18776241
Protein hnRNPA1 binds to a critical G-rich element of KRAS and unwinds G-quadruplex structures: implications in transcription.
Nucleic acids symposium series (2004) , 2008 | Pubmed ID: 18776302
Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.
Journal of medicinal chemistry Jan, 2009 | Pubmed ID: 19099510
Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription.
Nucleic acids research May, 2009 | Pubmed ID: 19282454
Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.
Chemical communications (Cambridge, England) Jan, 2010 | Pubmed ID: 20062883
The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.
The Journal of biological chemistry Jul, 2010 | Pubmed ID: 20457603
Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE.
Chemical communications (Cambridge, England) May, 2011 | Pubmed ID: 21424008
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
Molecular cell Jul, 2012 | Pubmed ID: 22705371
NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23508956
ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.
Cancer research Jul, 2013 | Pubmed ID: 23698467
Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.
Journal of the American Chemical Society Sep, 2014 | Pubmed ID: 25170678
Nuclear GIT2 is an ATM substrate and promotes DNA repair.
Molecular and cellular biology Apr, 2015 | Pubmed ID: 25605334
UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.
Cell reports Mar, 2015 | Pubmed ID: 25818288
MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Genes & development Sep, 2015 | Pubmed ID: 26338419
Single Molecule Analysis of Laser Localized Interstrand Crosslinks.
Frontiers in genetics , 2016 | Pubmed ID: 27242893
Reconstitution of anaphase DNA bridge recognition and disjunction.
Nature structural & molecular biology 09, 2018 | Pubmed ID: 30177760
PICH and TOP3A cooperate to induce positive DNA supercoiling.
Nature structural & molecular biology 04, 2019 | Pubmed ID: 30936532
National Institute on Aging, National Institutes of Health
University of Copenhagen
Jing Huang1,
Himabindu Gali1,
Julia Gichimu1,
Marina A. Bellani1,
Durga Pokharel1,
Manikandan Paramasivam1,
Michael M. Seidman1
1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
Jing Zhang*,1,
Jing Huang*,2,
Ishani Majumdar1,
Ryan C. James3,
Manikandan Paramasivam4,
Durga Pokharel5,
Himabindu Gali6,
Michael M Seidman1
1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health,
2Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University,
3Department of Molecular Biology and Genetics, Cornell University,
4Department of Cellular and Molecular Medicine, University of Copenhagen,
5, Horizon Discovery,
6, Boston University School of Medicine
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