Professor Julie McMullen (PhD) heads the Cardiac Hypertrophy Laboratory at the Baker Heart and Diabetes Institute (VIC, AUSTRALIA) and is Head of the Discovery & Preclinical Domain at the Institute. Her research interests include physiological and pathological cardiac hypertrophy, heart failure, atrial fibrillation, gene therapy and cardiotoxicity. Prof McMullen is recognised internationally for research which defined the molecular distinction between physiological and pathological heart growth/cardiac hypertrophy in mouse models of health and disease. She discovered that a signalling pathway activated with exercise (PI3K pathway) was critical for physiological hypertrophy (e.g. athlete’s heart) but not pathological hypertrophy (e.g. setting of hypertension). She has published her research in leading journals including PNAS, Circulation, Circulation-Heart Failure, Nature Communications, Cell Reports, and Diabetes. She sits on the Editorial Board of Clinical Science and the American Journal of Physiology-Heart and Circulatory Physiology, and is a Fellow of the American Heart Association and International Society for Heart Research.
Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2007 | Pubmed ID: 17202264
Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure.
Clinical and experimental pharmacology & physiology Apr, 2007 | Pubmed ID: 17324134
PI3K(p110alpha) inhibitors as anti-cancer agents: minding the heart.
Cell cycle (Georgetown, Tex.) Apr, 2007 | Pubmed ID: 17404510
Role of insulin-like growth factor 1 and phosphoinositide 3-kinase in a setting of heart disease.
Clinical and experimental pharmacology & physiology Mar, 2008 | Pubmed ID: 18290876
β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.
Journal of the American Heart Association Mar, 2017 | Pubmed ID: 28343149
Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.
Clinical science (London, England : 1979) Jun, 2017 | Pubmed ID: 28487469
The Interplay of Protein Coding and Non-Coding RNAs (circRNAs, lncRNAs) During Cardiac Differentiation.
EBioMedicine 11, 2017 | Pubmed ID: 29033140
The IGF1-PI3K-Akt Signaling Pathway in Mediating Exercise-Induced Cardiac Hypertrophy and Protection.
Advances in experimental medicine and biology , 2017 | Pubmed ID: 29098623
Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies.
Biochimica et biophysica acta 03, 2018 | Pubmed ID: 29217479
Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts.
Physiological reviews 01, 2018 | Pubmed ID: 29351515
Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling.
Clinical science (London, England : 1979) 02, 2018 | Pubmed ID: 29358507
Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β-adrenoceptor overexpression.
American journal of physiology. Heart and circulatory physiology 06, 2018 | Pubmed ID: 29424570
Standing up to the cardiometabolic consequences of hematological cancers.
Blood reviews 09, 2018 | Pubmed ID: 29496356
Divergent Effects of PKC (Protein Kinase C) α in the Human and Animal Heart? Therapeutic Implications for PKC Inhibitors in Cardiac Patients.
Circulation. Genomic and precision medicine 03, 2018 | Pubmed ID: 29540469
Improving the quality of preclinical research echocardiography: observations, training, and guidelines for measurement.
American journal of physiology. Heart and circulatory physiology 07, 2018 | Pubmed ID: 29677464
Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure.
Heart, lung & circulation Nov, 2018 | Pubmed ID: 29703647
Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure.
Scientific reports 05, 2018 | Pubmed ID: 29844319
PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart.
Experimental & molecular medicine 07, 2018 | Pubmed ID: 30050113
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets.
Cell reports 09, 2018 | Pubmed ID: 30184508
Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges.
Frontiers in pharmacology , 2018 | Pubmed ID: 30298011
Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling.
American journal of physiology. Heart and circulatory physiology 01, 2019 | Pubmed ID: 30387702
Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development.
Immunology and cell biology 03, 2019 | Pubmed ID: 30537346
Noncoding RNAs regulating cardiac muscle mass.
Journal of applied physiology (Bethesda, Md. : 1985) 08, 2019 | Pubmed ID: 30571279
Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2.
Cardiovascular research Nov, 2019 | Pubmed ID: 30596969
Author Correction: PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart.
Experimental & molecular medicine Mar, 2019 | Pubmed ID: 30846681
CORP: Practical tools for improving experimental design and reporting of laboratory studies of cardiovascular physiology and metabolism.
American journal of physiology. Heart and circulatory physiology 09, 2019 | Pubmed ID: 31347916
Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes.
American journal of physiology. Heart and circulatory physiology 04, 2020 | Pubmed ID: 32142359
Clusterin is regulated by IGF1-PI3K signaling in the heart: implications for biomarker and drug target discovery, and cardiotoxicity.
Archives of toxicology 05, 2020 | Pubmed ID: 32172307
Andersen-Tawil Syndrome Is Associated With Impaired PIP Regulation of the Potassium Channel Kir2.1.
Frontiers in pharmacology , 2020 | Pubmed ID: 32499698
Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes.
Diabetes 01, 2021 | Pubmed ID: 33115826
IGF1-PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity.
Journal of sport and health science Nov, 2020 | Pubmed ID: 33246162
Correction for McMullen et al., "Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy".
Molecular and cellular biology Jan, 2021 | Pubmed ID: 33495398
FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
American journal of physiology. Heart and circulatory physiology 04, 2021 | Pubmed ID: 33577435
Old Drug, New Trick: Tilorone, a Broad-Spectrum Antiviral Drug as a Potential Anti-Fibrotic Therapeutic for the Diseased Heart.
Pharmaceuticals (Basel, Switzerland) Mar, 2021 | Pubmed ID: 33804032
Proteome characterisation of extracellular vesicles isolated from heart.
Proteomics 07, 2021 | Pubmed ID: 33861516
Prevention of Pathological Atrial Remodeling and Atrial Fibrillation: JACC State-of-the-Art Review.
Journal of the American College of Cardiology 06, 2021 | Pubmed ID: 34082914
A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts.
STAR protocols Dec, 2021 | Pubmed ID: 34647038
Overexpression of Heat Shock Protein 70 Improves Cardiac Remodeling and Survival in Protein Phosphatase 2A-Expressing Transgenic Mice with Chronic Heart Failure.
Cells 11, 2021 | Pubmed ID: 34831402
Sebastian Bass-Stringer1,2,
Colleen J. Thomas2,3,
Clive N. May3,
Paul Gregorevic4,
Kate L. Weeks1,5,6,
Julie R. McMullen1,2,5,6,7
1, Baker Heart and Diabetes Institute,
2Department of Physiology, Anatomy and Microbiology, La Trobe University,
3Florey Institute of Neuroscience and Mental Health, University of Melbourne,
4Department of Physiology, Centre for Muscle Research (CMR), The University of Melbourne,
5Department of Diabetes, Central Clinical School, Monash University,
6Baker Department of Cardiometabolic Health, The University of Melbourne,
7Department of Physiology and Department of Medicine Alfred Hospital, Monash University
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