The overall goal of this video is to establish a mouse model of acute pancreatitis through retrograde injection of sodium taurocholate into biliopancreatic duct. All experiments involving animals were approved by the Animal Ethics Committee of Soo
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A mouse model of severe acute pancreatitis is described herein. The procedure presented here is very rapid, simple, and accessible, thereby potentially allowing the study of the molecular mechanisms and different therapeutic interventions in acute pancreatitis in a convenient way.