2022年"天府青城计划"天府科技领军人才项目（川清城1090号）、国家中医临床优秀人才培养计划（国家中医仁教函[2022]1号）、成都中医药大学医院"百人计划"项目（院办[2021]42）、四川省中医药管理局科研专项（2021MS093、 2021MS539、2023MS608）。

该临床研究方案经成都中医药大学附属医院呼吸内科临床研究审批委员会审批（备案号.肯塔基州2022010）。
1、设备准备
<ol><li>准备一次性无菌针灸针（尺寸为0.25 mm x 40 mm），艾条（尺寸为1.2 cm x 1.2 cm），医用灭菌拭子，碘伏拭子，打火机和几个60 mm x 60 mm纸板（见 图1）。</li>
</ol>2. 医生准备
<ol><li>确保患者符合《慢性阻塞性肺疾病初级保健指南》中 COPD 的诊断标准，并且有腹胀。</li>
	<li>排除有下列情况的患者:（1）皮肤溃疡、血糖控制不佳、血压控制不佳、头晕者;（2）患有矽肺病、肺结核、恶性肿瘤、哮喘、凝血障碍、严重心功能不全者;（3）风湿性心脏病、先天性心脏病、肾功能衰竭、肝功能衰竭等;（4）依从性差的。</li>
	<li>戴上医用口罩和帽子。</li>
	<li>用肥皂水洗手，保持干燥，并在握住针头操作之前使用酒精免洗手消毒液。</li>
</ol>3. 患者准备
<ol><li>要求患者排空膀胱。</li>
	<li>测量患者的血压、心率、呼吸频率和血氧饱和度。</li>
	<li>确保皮肤没有受损和溃烂。</li>
	<li>待上述基本体征正常后，指导患者选择仰卧位或俯卧位，露出穴位。</li>
	<li>建议患者在手术过程中出现不适时通知医生。</li>
</ol>4.穴位选择
<ol><li>用碘伏拭子擦拭要针刺部位的皮肤。</li>
	<li>根据标准化穴位，选择飞书（BL13）、太原（LU9）、定川（EX-B1）、足三里（ST36）、中湾（RN12）、天舒（ST25）24、25、26（见图2）。</li>
</ol>5. 针灸和针刺操作
<ol><li>将左手的五根手指平伸，将食指和中指分开刺伤的地方。</li>
	<li>用右手的拇指和食指握住针柄，中指末端靠近针尖，手指腹部靠在针体上。</li>
	<li>拇指和食指向下按压，同时中指弯曲，将针插入国际标准针灸角度和深度。</li>
	<li>沿针刺角度均匀提起并推入针柄，深度约3mm，频率约60次/分27。</li>
	<li>将针柄前后旋转 180 度或更小的角度;频率约为60次/分钟，直到患者感觉De-qi27。</li>
</ol>6.放置艾条
<ol><li>从距离皮肤28 厘米的底部点燃艾条，使患者在体表上产生温暖的感觉和发红。治疗大约需要 30 分钟。</li>
</ol>7.放置纸板
<ol><li>将 60 毫米 x 60 毫米的纸板放在艾条下方，以防止灰烬灼伤皮肤，直到艾条烧坏（见 图 3）。</li>
</ol>8. 挑针
<ol><li>用竹签的末端轻轻捡起烧焦的艾条。</li>
	<li>用手中的医用消毒棉签轻轻按压针头部位。</li>
	<li>用针头轻轻扭转，慢慢将它们提升到皮下，放置片刻，然后取出。</li>
	<li>针头拔出后，用医用消毒棉签轻轻按压针孔片刻，以防止出血，减轻疼痛。</li>
	<li>拔针后，仔细检查针孔是否出血，询问患者是否有不适，检查针头数量是否缺失。</li>
</ol>

温针灸缓解慢性阻塞性肺病腹胀

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作者没有利益冲突需要声明。

众所周知，慢性阻塞性肺病引起的腹胀的发病机制尚不完全清楚，这阻碍了新疗法和新药的开发。近年来，温针灸被广泛应用于COPD合并腹胀。温针灸的治疗机理主要是针灸的效果、艾灸的温热作用、针体的导热作用31。艾灸的重点是穴位的局部变暖。它激活局部特异性受体、热休克蛋白、热敏免疫细胞等，发挥温经、开通侧支的局部作用32。现代中医认为，RN12?...

慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统慢性消耗性疾病。慢性阻塞性肺病患者主要表现为慢性咳嗽和咳痰，病情进展，肺功能逐渐下降。疾病后期可并发慢性肺心病、呼吸衰竭、心力衰竭等，严重影响患者生活质量。据报道，肠道微生物群的改变与 COPD1 的疾病进展有关。除肺部症状外，40.31%的稳定期COPD患者报告腹胀。腹胀可对肺部症状恶化、增加 COPD 急性加重的频率以及损害稳定期 COPD 患者的生活质量产生重大影响 2,3。慢性阻塞性肺病腹胀的原因被认为是多因素的，可能包括以下几点:（1）细菌菌群失调;（2）腹水，增加腹内压;（3）电解质紊乱;（4）右心衰竭和肝脏或消化道充血;（5）长期卧床休息4;（6）药物5和机械通气6。
有中医学者提出，慢性阻塞性肺病的发展过程是四种状态的过程:（1）肺气虚;（2）脾气虚;（3）肾气虚;（4）阴阳虚 7,8.如果脾脏无法运输和转化，胃虚弱而无法接收，则可能会发生腹胀，进而导致肌肉因缺乏化学来源而变薄和无力9.目前，临床上常用的COPD药物有支气管扩张剂、糖皮质激素、抗生素等药物10。目前尚无指南规定COPD合并腹胀的标准化治疗方案，腹胀通常以对症治疗。
中医温针灸，可引导气疏通经络，活血化瘀，补虚温阳，消寒。它们可以产生抗氧化物质，从而发挥调节作用，从而促进免疫系统应激反应并改善血液循环11,12。温针灸可用于治疗颈椎病13、膝关节炎14、痛经15、便秘16、肠易激综合征17等。实验研究表明，针灸可以通过调节脑肠轴18来缓解腹胀。针灸联合艾灸可显着减少腹胀19，腹胀可以通过调节血浆前列腺素 E2 和血浆和胃粘膜组织中的胃泌素水平20 来发挥。同时，温针灸在改善功能性消化不良症状方面优于促动力药和假针灸21。针灸可以加强横膈膜，缓解呼吸肌疲劳，以及改善二氧化碳潴留和缺氧，预防和缓解呼吸衰竭22。温针和艾灸可改善稳定期慢性阻塞性肺病患者的肺功能、临床症状和生活质量23,24。
根据中医"肺与大肠内外关系"的理论，本研究采用温针灸治疗，旨在促进胃肠功能的恢复，提高肺功能和生活质量。温针和艾灸是高效、易于执行且价格低廉的中医治疗形式。综上所述，有必要就如何正确操作使用温针和艾灸来缓解腹胀性COPD提出标准方案。本文介绍如何正确操作使用温针和艾灸治疗来缓解腹胀的COPD。

<table><tbody><tr><td>Moxa stick</td><td>Dr. Moxi</td><td>N/A</td><td>size: 1.2 cm x 1.2 cm</td></tr><tr><td>Disposable sterile acupuncture needle</td><td>HWATO</td><td>2001-0020</td><td>size:&amp;nbsp; 0.25 mm x 40 mm</td></tr><tr><td>Iodophor swabs</td><td>BEIJIAER</td><td>20162140536</td><td></td></tr><tr><td>Cardboard</td><td>In-house</td><td>In-house</td><td>size: 60 mm x 60 mm&amp;nbsp;</td></tr></tbody></table>

a preliminary study on warm acupuncture and moxibustion for treating chronic obstructive pulmonary disease with abdominal distension

大多数 COPD 患者同时存在腹胀，这已被证明会对 COPD 患者的肺部症状、急性加重频率和生活质量产生不利影响。温针灸已被证明可有效缓解慢性阻塞性肺病合并腹胀患者的症状。温针和艾灸是高效、易于执行且价格低廉的中医治疗形式。温针灸的规范做法对于COPD合并腹胀的治疗非常重要。具体步骤包括通过辨证治疗选择合适的穴位进行针刺，以及选择合适长度的艾条进行脱气后约30分钟的艾灸。治疗过程持续一周。具体评估以下指标:COPD评估测试（CAT）和腹胀视觉模拟量表（VAS）的评分。本文将清楚地说明如何规范温针灸的操作，以缓解COPD合并腹胀。

一般条件 将12例COPD合并腹胀患者（表1）分为观察组和对照组，每组6例。所有患者均符合《慢性阻塞性肺疾病初级保健指南（2018）》29 的诊断标准，并有腹胀。对照组给予假针刺。我们选择与观察组相同的穴位，在这些穴位旁边 2.5 厘米处垂直插入皮肤，并在没有针刺和艾灸的情况下将它们表面刺穿 1-3 毫米。对照组患者根据《慢性阻塞性肺疾病初级?...

Watch this Scientific Journal Video about An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension at JoVE.com

作者聚焦:慢性阻塞性肺疾病腹胀的有效中医治疗方法 

在这里，我们提出了一种正确操作温针灸治疗腹胀慢性阻塞性肺病 （COPD） 的方案。

温针灸治疗慢性阻塞性肺疾病伴腹胀的初步研究

Most patients with COPD have a combination of abdominal distension, which has been shown to adversely affect pulmonary symptoms, frequency of acute ...

我们提出了一种温针灸的标准化操作，用于治疗慢性阻塞性肺疾病（COPD）合并腹胀。这种方法可以帮助回答腹胀性阻塞性肺病领域的关键问题。温针和艾灸的手动优点包括该方法操作效率高、性能易用、价格实惠。这些形式的中医治疗可以使许多患者受益。我们的实验室将致力于研究温针灸缓解腹胀性阻塞性肺病的基本机制。我们未来的工作将集中在建立更智能的温热针灸操作上。

a-preliminary-study-on-warm-acupuncture-moxibustion-for-treating

Research

JoVE Journal

Medicine

A Preliminary Study on Warm Acupuncture and Moxibustion for Treating Chronic Obstructive Pulmonary Disease with Abdominal Distension

1.3K 次观看.  Hospital of Chengdu University of Traditional Chinese Medicine. 我们提出了一种温针灸的标准化操作，用于治疗慢性阻塞性肺疾病（COPD）合并腹胀。这种方法可以帮助回答腹胀性阻塞性肺病领域的关键问题。温针和艾灸的手动优点包括该方法操作效率高、性能易用、价格实惠。这些形式的中医治疗可以使许多患者受益。我们的实验室将致力于研究温针灸缓解腹胀性阻塞性肺病的基本机制。我们未来的工作将集中在建立更智能的温热...

视频: 作者聚焦:慢性阻塞性肺疾病腹胀的有效中医治疗方法 

壮药系大鼠艾灸标准化操作流程

Medicated Thread Moxibustion Therapy of Zhuang Medicine and its Application in a Rat Model of Cold-Congealing Syndrome of Primary Dysmenorrhea

Zhuang medicine thread moxibustion therapy is one of the national intangible cultural heritages. It is a Zhuang medicine characteristic therapy that involves igniting ramie thread soaked in Zhuang medicine preparation solution and directly moxibustion on a certain acupoint or part of the body surface. This treatment method is characterized by combining drug, acupoints, and moxibustion, stimulating the skin's receptors at the acupoints through the warmth of moxibustion, affecting the biochemical metabolism of histiocyte and the function of the nervous system so that the drug ingredients can be absorbed through the skin. However, the therapeutic effect of Zhuang medicine line moxibustion is influenced by factors such as moxibustion intensity, heat intensity, and moxibustion frequency. Manual operation cannot precisely control each influencing factor. Here, we design a Zhuang medicine line moxibustion simulation instrument to maintain a constant force, heat, and frequency. The frequency and heat can be adjusted according to experimental needs, and it can be applied to the study of analgesic experiments to observe the analgesic effect of Zhuang medicine line moxibustion on pain animal models to solve the standardization problem of Zhuang medicine line moxibustion in the operation process of experimental animals.This study establishes a model of primary dysmenorrhea in rats with cold coagulation syndrome and provides a detailed introduction to the preparation, process, and precautions of Zhuang medicine thread moxibustion on the model of primary dysmenorrhea in rats with cold coagulation syndrome. The intervention of Zhuang medicine thread moxibustion on primary dysmenorrhea in rats with cold coagulation syndrome is evaluated by twisting score and infrared thermal imaging body surface temperature detection, intuitively demonstrating the therapeutic effect of Zhuang medicine thread moxibustion, and a preliminary analysis of its mechanism of action is conducted.

作者聚焦：展示自动化壮药线艾灸模拟器的治疗效果

This article demonstrates the standardized operation process of Zhuang medicine line moxibustion in experimental animals. To achieve repeatability and accuracy of Zhuang medicine line moxibustion, we developed a simulator to maintain strength, heat, and frequency. We constructed a dysmenorrhea model for experimental verification in rats with cold coagulation syndrome.

壮药药用线灸疗法及其在原发性痛经冷凝证大鼠模型中的应用

Zhuang medicine thread moxibustion therapy is one of the national intangible cultural heritages. It is a Zhuang medicine characteristic therapy that ...

科研

行为学

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Sensitization to grass pollen imposes a global risk for allergic airway diseases. Although prevention relies on local investigation of the pollen allergens, data on this topic are limited in southern China. Any available data were obtained by self-report questionnaires, skin prick tests, and total or specific IgE tests using crude extracts. For many reasons, these methods are unreliable. Serum sIgE reactivity to Bermuda grass, Timothy grass, and Humulus scandens allergens in a cohort of patients from Greater Guangzhou (southern China&#39;s largest city and its outskirts) with allergic rhinitis and/or asthma were examined using a fully-automated immunoassay analyzer as a component-resolved diagnostics (CRD) tool.
For the first time, a considerably high prevalence of Bermuda grass sIgE positivity was demonstrated in Chinese southerners with allergic rhinitis and/or asthma. In these patients, a subtle prevalence of sensitization to Timothy grass and Humulus scandens was also noted, which may arise from cross-reactivity, as the latter two are not common in the region. This was also supported by the detection of allergen components.
Fully-automated immunoassay analyzers may offer satisfactory consistency between regions, laboratories, and institutions and over time. The automaticity of the instrument may enable a standardized detection that would not have been readily revealed before the advent of CRD.
This is a study that uses a CRD approach to investigate sensitization to grass pollen allergens in southern China. It adds to current evidence in the literature. Future studies are needed to validate these findings. However, although CRD is a useful tool, the findings made with the fully-automated immunoassay analyzer should not substitute for other laboratory investigations, clinical evaluations, and physician expertise.

This work describes a protocol that uses a component-resolved approach to study sensitization to grass pollen allergens in a cohort of patients from southern China with allergic rhinitis and/or asthma.

中国南方与过敏性鼻炎和/或哮喘的花粉过敏原研究的成分分析诊断方法

Sensitization to grass pollen imposes a global risk for allergic airway diseases. Although prevention relies on local investigation of the pollen ...

医学

探索 Du-Moxibust 治疗强直性脊柱炎的治疗潜力

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a progressively worsening and disabling form of arthritis that primarily affects the axial skeleton. This disease mainly involves the spine and the sacroiliac joint. Fusion of the spine and the sacroiliac joint may occur in the later stage of the disease, resulting in spinal stiffness and kyphosis, as well as difficulty in walking, which seriously affects the quality of work and daily living activities and imposes a heavy burden on the patient, the family, and society. Increasing attention has been paid to non-pharmacotherapy as an alternative therapy for AS. Moxibustion is an ancient therapeutic technique used in Traditional Chinese Medicine (TCM). Du-moxibustion therapy, a unique and innovative external treatment developed on the basis of ordinary moxibustion, has a definite therapeutic effect on AS. Du-moxibustion skillfully combines the compatible techniques of TCM to integrate meridians, acupoints, Chinese herbal medicine, and moxibustion. This paper describes the operation procedures and precautions to be taken during Du-moxibustion in experimental mice in detail to provide an experimental basis for the study of the mechanism of Du-moxibustion in the treatment of AS.

作者聚焦:评估传统中医疗法治疗小鼠强直性脊柱炎 

This paper describes in detail the operation procedures and precautions to be taken during Du-moxibustion in the treatment of ankylosing spondylitis in experimental mice.

强直性脊柱炎小鼠模型中的杜艾灸

Ankylosing spondylitis (AS) is a progressively worsening and disabling form of arthritis that primarily affects the axial skeleton. This disease mainly ...

免疫与感染

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Bronchial asthma is a chronic inflammatory disease of the airway which can lead to symptoms such as recurrent wheezing, shortness of breath, chest tightness, or cough, as a result of increased airway reactivity. With high diurnal variation, these symptoms often occur or worsen at night or in the morning. By burning and roasting the Chinese medica above human acupoints, moxibustion is a type of treatment that stimulates the activity of the human meridians through drugs and heat stimulation to prevent and treat diseases. According to the principle of syndrome differentiation and treatment of traditional Chinese medicine, acupoints are selected on the corresponding parts, which has a definite effect. It is regarded as a characteristic traditional Chinese medicine therapy for bronchial asthma. This protocol elaborates the methods and steps of patient management, material preparation, selection of acupoints, operation, and postoperative nursing to ensure safe and effective moxibustion treatment to significantly improve the clinical symptoms and quality of life of patients with bronchial asthma.

This protocol presents a curative procedure of moxibustion in treating patients with bronchial asthma.

支气管哮喘的中医特色疗法:艾灸

Bronchial asthma is a chronic inflammatory disease of the airway which can lead to symptoms such as recurrent wheezing, shortness of breath, chest ...

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a common and frequent disease in elderly patients, with a tendency for progressive exacerbation. Constipation that reduces the quality of life and triggers the risk of diseases is a common concomitant symptom in patients with COPD. Currently, western medical treatment does not achieve the desired results for patients. A high recurrence rate accompanies it, whereas traditional Chinese medicine (TCM) has a long history and rich experience in treating chronic diseases. Both acupoint application and acupoint massage are characteristic therapies of TCM, with minor side effects, high safety, simple operation, and outstanding advantages. They are effective in treating constipation for patients with COPD and are considered an ideal alternative therapy for patients with chronic constipation. The purpose of this article is to introduce the method of acupoint application combined with acupoint massage for the treatment of constipation in patients with COPD, including the selection of points, items, treatment time, and operation procedure.

Here we demonstrate acupoint application combined with acupoint massage for treating constipation in a patient with chronic obstructive pulmonary disease (COPD).

穴位应用联合穴位按摩治疗慢性阻塞性肺疾病患者便秘

Chronic obstructive pulmonary disease (COPD) is a common and frequent disease in elderly patients, with a tendency for progressive exacerbation. ...

针灸刺激耳朵以缓解 COPD 患者的睡眠障碍

Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders

Chronic obstructive pulmonary disease (COPD) is a clinical syndrome characterized by persistent and irreversible airflow limitation and chronic respiratory symptoms. It has a wide spectrum of complications, and sleep disorders, as part of it, are common in severe cases, especially in elderly patients. Long-term lack of sleep may lead to the aggravation of the original disease, reducing patients' quality of life. Benzodiazepines are mainly used for symptomatic treatment of COPD combined with sleep disorders. However, such drugs have the side effect of respiratory central inhibition and could probably aggravate hypoxia symptoms. Auricular acupuncture is a special method of treating physical and psychosomatic dysfunctions by stimulating specific points in the ear. This article explains the specific methods of clinical operation of auricular acupuncture in detail, including assessment of patient eligibility, medical devices used, acupuncture points, course of treatment, post-treatment care, responses to emergencies, etc. The Pittsburgh sleep quality index (PSQI) and chronic obstructive pulmonary disease assessment scale (CAT) were used as the observational index of this method. So far, clinical reports have proved that auricular acupuncture has a definite curative effect in the treatment of COPD combined with sleep disorders, and its advantages of simple operation, few adverse reactions are worthy of further study and promotion, which provide a reference for the clinical treatment of such diseases.

作者聚焦:利用中医耳针疗法改善睡眠障碍 

This protocol introduces an effective method to improve the sleep condition of patients with chronic obstructive pulmonary disease and alleviate cough symptoms by using auricular acupuncture techniques to percutaneously stimulate specific acupoints in the patients' ears.

温针灸治疗慢性阻塞性肺疾病伴腹胀的初步研究

副本

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壮药药用线灸疗法及其在原发性痛经冷凝证大鼠模型中的应用

壮药药用线灸疗法及其在原发性痛经冷凝证大鼠模型中的应用

壮药药用线灸疗法及其在原发性痛经冷凝证大鼠模型中的应用

中国南方与过敏性鼻炎和/或哮喘的花粉过敏原研究的成分分析诊断方法

强直性脊柱炎小鼠模型中的杜艾灸

强直性脊柱炎小鼠模型中的杜艾灸

强直性脊柱炎小鼠模型中的杜艾灸

支气管哮喘的中医特色疗法:艾灸

穴位应用联合穴位按摩治疗慢性阻塞性肺疾病患者便秘

耳针作为慢性阻塞性肺疾病合并睡眠障碍的中医疗法