2022年"天府青城计划"天府科技领军人才项目（川清城1090号）、国家中医临床优秀人才培养计划（国家中医仁教函[2022]1号）、成都中医药大学医院"百人计划"项目（院办[2021]42）、四川省中医药管理局科研专项（2021MS093、 2021MS539、2023MS608）。

该临床研究方案经成都中医药大学附属医院呼吸内科临床研究审批委员会审批（备案号.肯塔基州2022010）。
1、设备准备
<ol><li>准备一次性无菌针灸针（尺寸为0.25 mm x 40 mm），艾条（尺寸为1.2 cm x 1.2 cm），医用灭菌拭子，碘伏拭子，打火机和几个60 mm x 60 mm纸板（见 图1）。</li>
</ol>2. 医生准备
<ol><li>确保患者符合《慢性阻塞性肺疾病初级保健指南》中 COPD 的诊断标准，并且有腹胀。</li>
	<li>排除有下列情况的患者:（1）皮肤溃疡、血糖控制不佳、血压控制不佳、头晕者;（2）患有矽肺病、肺结核、恶性肿瘤、哮喘、凝血障碍、严重心功能不全者;（3）风湿性心脏病、先天性心脏病、肾功能衰竭、肝功能衰竭等;（4）依从性差的。</li>
	<li>戴上医用口罩和帽子。</li>
	<li>用肥皂水洗手，保持干燥，并在握住针头操作之前使用酒精免洗手消毒液。</li>
</ol>3. 患者准备
<ol><li>要求患者排空膀胱。</li>
	<li>测量患者的血压、心率、呼吸频率和血氧饱和度。</li>
	<li>确保皮肤没有受损和溃烂。</li>
	<li>待上述基本体征正常后，指导患者选择仰卧位或俯卧位，露出穴位。</li>
	<li>建议患者在手术过程中出现不适时通知医生。</li>
</ol>4.穴位选择
<ol><li>用碘伏拭子擦拭要针刺部位的皮肤。</li>
	<li>根据标准化穴位，选择飞书（BL13）、太原（LU9）、定川（EX-B1）、足三里（ST36）、中湾（RN12）、天舒（ST25）24、25、26（见图2）。</li>
</ol>5. 针灸和针刺操作
<ol><li>将左手的五根手指平伸，将食指和中指分开刺伤的地方。</li>
	<li>用右手的拇指和食指握住针柄，中指末端靠近针尖，手指腹部靠在针体上。</li>
	<li>拇指和食指向下按压，同时中指弯曲，将针插入国际标准针灸角度和深度。</li>
	<li>沿针刺角度均匀提起并推入针柄，深度约3mm，频率约60次/分27。</li>
	<li>将针柄前后旋转 180 度或更小的角度;频率约为60次/分钟，直到患者感觉De-qi27。</li>
</ol>6.放置艾条
<ol><li>从距离皮肤28 厘米的底部点燃艾条，使患者在体表上产生温暖的感觉和发红。治疗大约需要 30 分钟。</li>
</ol>7.放置纸板
<ol><li>将 60 毫米 x 60 毫米的纸板放在艾条下方，以防止灰烬灼伤皮肤，直到艾条烧坏（见 图 3）。</li>
</ol>8. 挑针
<ol><li>用竹签的末端轻轻捡起烧焦的艾条。</li>
	<li>用手中的医用消毒棉签轻轻按压针头部位。</li>
	<li>用针头轻轻扭转，慢慢将它们提升到皮下，放置片刻，然后取出。</li>
	<li>针头拔出后，用医用消毒棉签轻轻按压针孔片刻，以防止出血，减轻疼痛。</li>
	<li>拔针后，仔细检查针孔是否出血，询问患者是否有不适，检查针头数量是否缺失。</li>
</ol>

温针灸缓解慢性阻塞性肺病腹胀

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作者没有利益冲突需要声明。

众所周知，慢性阻塞性肺病引起的腹胀的发病机制尚不完全清楚，这阻碍了新疗法和新药的开发。近年来，温针灸被广泛应用于COPD合并腹胀。温针灸的治疗机理主要是针灸的效果、艾灸的温热作用、针体的导热作用31。艾灸的重点是穴位的局部变暖。它激活局部特异性受体、热休克蛋白、热敏免疫细胞等，发挥温经、开通侧支的局部作用32。现代中医认为，RN12?...

慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统慢性消耗性疾病。慢性阻塞性肺病患者主要表现为慢性咳嗽和咳痰，病情进展，肺功能逐渐下降。疾病后期可并发慢性肺心病、呼吸衰竭、心力衰竭等，严重影响患者生活质量。据报道，肠道微生物群的改变与 COPD1 的疾病进展有关。除肺部症状外，40.31%的稳定期COPD患者报告腹胀。腹胀可对肺部症状恶化、增加 COPD 急性加重的频率以及损害稳定期 COPD 患者的生活质量产生重大影响 2,3。慢性阻塞性肺病腹胀的原因被认为是多因素的，可能包括以下几点:（1）细菌菌群失调;（2）腹水，增加腹内压;（3）电解质紊乱;（4）右心衰竭和肝脏或消化道充血;（5）长期卧床休息4;（6）药物5和机械通气6。
有中医学者提出，慢性阻塞性肺病的发展过程是四种状态的过程:（1）肺气虚;（2）脾气虚;（3）肾气虚;（4）阴阳虚 7,8.如果脾脏无法运输和转化，胃虚弱而无法接收，则可能会发生腹胀，进而导致肌肉因缺乏化学来源而变薄和无力9.目前，临床上常用的COPD药物有支气管扩张剂、糖皮质激素、抗生素等药物10。目前尚无指南规定COPD合并腹胀的标准化治疗方案，腹胀通常以对症治疗。
中医温针灸，可引导气疏通经络，活血化瘀，补虚温阳，消寒。它们可以产生抗氧化物质，从而发挥调节作用，从而促进免疫系统应激反应并改善血液循环11,12。温针灸可用于治疗颈椎病13、膝关节炎14、痛经15、便秘16、肠易激综合征17等。实验研究表明，针灸可以通过调节脑肠轴18来缓解腹胀。针灸联合艾灸可显着减少腹胀19，腹胀可以通过调节血浆前列腺素 E2 和血浆和胃粘膜组织中的胃泌素水平20 来发挥。同时，温针灸在改善功能性消化不良症状方面优于促动力药和假针灸21。针灸可以加强横膈膜，缓解呼吸肌疲劳，以及改善二氧化碳潴留和缺氧，预防和缓解呼吸衰竭22。温针和艾灸可改善稳定期慢性阻塞性肺病患者的肺功能、临床症状和生活质量23,24。
根据中医"肺与大肠内外关系"的理论，本研究采用温针灸治疗，旨在促进胃肠功能的恢复，提高肺功能和生活质量。温针和艾灸是高效、易于执行且价格低廉的中医治疗形式。综上所述，有必要就如何正确操作使用温针和艾灸来缓解腹胀性COPD提出标准方案。本文介绍如何正确操作使用温针和艾灸治疗来缓解腹胀的COPD。

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	<tbody>
		<tr>
			<td>Moxa stick</td>
			<td>Dr. Moxi</td>
			<td>N/A</td>
			<td>size: 1.2 cm x 1.2 cm</td>
		</tr>
		<tr>
			<td>Disposable sterile acupuncture needle</td>
			<td>HWATO</td>
			<td>2001-0020</td>
			<td>size:&#160; 0.25 mm x 40 mm</td>
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			<td>Iodophor swabs</td>
			<td>BEIJIAER</td>
			<td>20162140536</td>
			<td></td>
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			<td>Cardboard</td>
			<td>In-house</td>
			<td>In-house</td>
			<td>size: 60 mm x 60 mm&#160;</td>
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a preliminary study on warm acupuncture and moxibustion for treating chronic obstructive pulmonary disease with abdominal distension

大多数 COPD 患者同时存在腹胀，这已被证明会对 COPD 患者的肺部症状、急性加重频率和生活质量产生不利影响。温针灸已被证明可有效缓解慢性阻塞性肺病合并腹胀患者的症状。温针和艾灸是高效、易于执行且价格低廉的中医治疗形式。温针灸的规范做法对于COPD合并腹胀的治疗非常重要。具体步骤包括通过辨证治疗选择合适的穴位进行针刺，以及选择合适长度的艾条进行脱气后约30分钟的艾灸。治疗过程持续一周。具体评估以下指标:COPD评估测试（CAT）和腹胀视觉模拟量表（VAS）的评分。本文将清楚地说明如何规范温针灸的操作，以缓解COPD合并腹胀。

一般条件 将12例COPD合并腹胀患者（表1）分为观察组和对照组，每组6例。所有患者均符合《慢性阻塞性肺疾病初级保健指南（2018）》29 的诊断标准，并有腹胀。对照组给予假针刺。我们选择与观察组相同的穴位，在这些穴位旁边 2.5 厘米处垂直插入皮肤，并在没有针刺和艾灸的情况下将它们表面刺穿 1-3 毫米。对照组患者根据《慢性阻塞性肺疾病初级?...

Watch this Scientific Journal Video about An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension at JoVE.com

作者聚焦:慢性阻塞性肺疾病腹胀的有效中医治疗方法 

在这里，我们提出了一种正确操作温针灸治疗腹胀慢性阻塞性肺病 （COPD） 的方案。

温针灸治疗慢性阻塞性肺疾病伴腹胀的初步研究

Most patients with COPD have a combination of abdominal distension, which has been shown to adversely affect pulmonary symptoms, frequency of acute ...

我们提出了一种温针灸的标准化操作，用于治疗慢性阻塞性肺疾病（COPD）合并腹胀。这种方法可以帮助回答腹胀性阻塞性肺病领域的关键问题。温针和艾灸的手动优点包括该方法操作效率高、性能易用、价格实惠。这些形式的中医治疗可以使许多患者受益。我们的实验室将致力于研究温针灸缓解腹胀性阻塞性肺病的基本机制。我们未来的工作将集中在建立更智能的温热针灸操作上。

a-preliminary-study-on-warm-acupuncture-moxibustion-for-treating

Research

JoVE Journal

Medicine

A Preliminary Study on Warm Acupuncture and Moxibustion for Treating Chronic Obstructive Pulmonary Disease with Abdominal Distension

1.2K 次观看.  Hospital of Chengdu University of Traditional Chinese Medicine. 我们提出了一种温针灸的标准化操作，用于治疗慢性阻塞性肺疾病（COPD）合并腹胀。这种方法可以帮助回答腹胀性阻塞性肺病领域的关键问题。温针和艾灸的手动优点包括该方法操作效率高、性能易用、价格实惠。这些形式的中医治疗可以使许多患者受益。我们的实验室将致力于研究温针灸缓解腹胀性阻塞性肺病的基本机制。我们未来的工作将集中在建立更智能的温热...

视频: 作者聚焦:慢性阻塞性肺疾病腹胀的有效中医治疗方法 

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung parenchymal destruction. It has a very high incidence in aging populations. The current conventional therapies for COPD focus mainly on symptom-modifying drugs; thus, the development of new therapies is urgently needed. Qualified animal models of COPD could help to characterize the underlying mechanisms and can be used for new drug screening. Current COPD models, such as lipopolysaccharide (LPS) or the porcine pancreatic elastase (PPE)-induced emphysema model, generate COPD-like lesions in the lungs and airways but do not otherwise resemble the pathogenesis of human COPD. A cigarette smoke (CS)-induced model remains one of the most popular because it not only simulates COPD-like lesions in the respiratory system, but it is also based on one of the main hazardous materials that causes COPD in humans. However, the time-consuming and labor-intensive aspects of the CS-induced model dramatically limit its application in new drug screening. In this study, we successfully generated a new COPD model by exposing mice to high levels of ozone. This model demonstrated the following: 1) decreased forced expiratory volume 25, 50, and 75/forced vital capacity (FEV25/FVC, FEV50/FVC, and FEV75/FVC), indicating the deterioration of lung function; 2) enlarged lung alveoli, with lung parenchymal destruction; 3) reduced fatigue time and distance; and 4) increased inflammation. Taken together, these data demonstrate that the ozone exposure (OE) model is a reliable animal model that is similar to humans because ozone overexposure is one of the etiological factors of COPD. Additionally, it only took 6 - 8 weeks, based on our previous work, to create an OE model, whereas it requires 3 - 12 months to induce the cigarette smoke model, indicating that the OE model might be a good choice for COPD research.

This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.

反复臭氧暴露对小鼠慢性阻塞性肺疾病模型的产生

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung parenchymal destruction. It has a very high ...

科研

医学

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a common and frequent disease in elderly patients, with a tendency for progressive exacerbation. Constipation that reduces the quality of life and triggers the risk of diseases is a common concomitant symptom in patients with COPD. Currently, western medical treatment does not achieve the desired results for patients. A high recurrence rate accompanies it, whereas traditional Chinese medicine (TCM) has a long history and rich experience in treating chronic diseases. Both acupoint application and acupoint massage are characteristic therapies of TCM, with minor side effects, high safety, simple operation, and outstanding advantages. They are effective in treating constipation for patients with COPD and are considered an ideal alternative therapy for patients with chronic constipation. The purpose of this article is to introduce the method of acupoint application combined with acupoint massage for the treatment of constipation in patients with COPD, including the selection of points, items, treatment time, and operation procedure.

Here we demonstrate acupoint application combined with acupoint massage for treating constipation in a patient with chronic obstructive pulmonary disease (COPD).

穴位应用联合穴位按摩治疗慢性阻塞性肺疾病患者便秘

Chronic obstructive pulmonary disease (COPD) is a common and frequent disease in elderly patients, with a tendency for progressive exacerbation. ...

针灸刺激耳朵以缓解 COPD 患者的睡眠障碍

Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders

Chronic obstructive pulmonary disease (COPD) is a clinical syndrome characterized by persistent and irreversible airflow limitation and chronic respiratory symptoms. It has a wide spectrum of complications, and sleep disorders, as part of it, are common in severe cases, especially in elderly patients. Long-term lack of sleep may lead to the aggravation of the original disease, reducing patients' quality of life. Benzodiazepines are mainly used for symptomatic treatment of COPD combined with sleep disorders. However, such drugs have the side effect of respiratory central inhibition and could probably aggravate hypoxia symptoms. Auricular acupuncture is a special method of treating physical and psychosomatic dysfunctions by stimulating specific points in the ear. This article explains the specific methods of clinical operation of auricular acupuncture in detail, including assessment of patient eligibility, medical devices used, acupuncture points, course of treatment, post-treatment care, responses to emergencies, etc. The Pittsburgh sleep quality index (PSQI) and chronic obstructive pulmonary disease assessment scale (CAT) were used as the observational index of this method. So far, clinical reports have proved that auricular acupuncture has a definite curative effect in the treatment of COPD combined with sleep disorders, and its advantages of simple operation, few adverse reactions are worthy of further study and promotion, which provide a reference for the clinical treatment of such diseases.

作者聚焦:利用中医耳针疗法改善睡眠障碍 

This protocol introduces an effective method to improve the sleep condition of patients with chronic obstructive pulmonary disease and alleviate cough symptoms by using auricular acupuncture techniques to percutaneously stimulate specific acupoints in the patients' ears.

耳针作为慢性阻塞性肺疾病合并睡眠障碍的中医疗法

Chronic obstructive pulmonary disease (COPD) is a clinical syndrome characterized by persistent and irreversible airflow limitation and chronic ...

使用改进的 Videman 方法在兔子中建立 KOA 模型

Application of Acupotomy in a Knee Osteoarthritis Model in Rabbit

Knee osteoarthritis (KOA) is one of the most frequently encountered diseases in the orthopedic department, which seriously reduces the quality of life of people with KOA. Among several pathogenic factors, the biomechanical imbalance of the knee joint is one of the main causes of KOA. Acupotomology believes that restoring the mechanical balance of the knee joint is the key to treating KOA. Clinical studies have shown that acupotomy can effectively reduce pain and improve knee mobility by reducing adhesion, contracture of soft tissues, and stress concentration points in muscles and tendons around the knee joint. 
In this protocol, we used the modified Videman method to establish a KOA model by immobilizing the left hindlimb in a straight position. We have outlined the method of operation and the precautions related to acupotomy in detail and evaluated the efficacy of acupotomy in conjunction with the theory of "Modulating Muscles and Tendons to Treat Bone Disorders" through the detection of the mechanical properties of quadriceps femoris and tendon, as well as cartilage mechanics and morphology. The results show that acupotomy has a protective effect on cartilage by adjusting the mechanical properties of the soft tissues around the knee joint, improving the cartilage stress environment, and delaying cartilage degeneration.

作者聚焦:研究针尖切开术治疗膝骨关节炎的作用机制

In this protocol, a knee osteoarthritis model was prepared using the modified Videman method, and the operation procedures and precautions of acupotomy are detailed. The effectiveness of acupotomy has been demonstrated by testing the mechanical properties of quadriceps femoris and tendon and the mechanical and morphological properties of cartilage.

针灸术在兔膝骨关节炎模型中的应用

Knee osteoarthritis (KOA) is one of the most frequently encountered diseases in the orthopedic department, which seriously reduces the quality of life of ...

<meta charset="utf8"></head><body>中医耳尖疗法治疗 COPD 患者喘息

Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease 

Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it is characterized by emphysematous destruction of the lungs. Shortness of breath is one of the main clinical symptoms. Auricular acupressure is a clinical therapy characteristic of Chinese medicine that treats the disease by compressing ear points. Usually, the seeds of Vaccaria segetalis are used to stimulate ear points, which has the effect of regulating qi and alleviating wheezing. In this paper, we propose this characteristic therapy of traditional Chinese medicine (TCM) for the clinical symptoms of wheezing of lung and kidney qi deficiency type in stable COPD patients. Ear points are selected as the treatment protocol for Lung (CO14), Spleen (CO13), Kidney (CO10), Shen Men (TF4), and Ping Chuan (AT1.2.4i) points. The protocol describes a case study using auricular acupressure for a patient with chronic obstructive pulmonary disease to relieve wheezing symptoms.

<meta charset="utf8"></head><body>作者聚焦:耳压豆疗法在减轻喘息症状方面的疗效

This protocol describes an effective therapy using auricular acupressure to relieve wheezing symptoms in stable chronic obstructive pulmonary disease.

耳穴按压作为稳定期慢性阻塞性肺疾病喘息的辅助治疗 

Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it is characterized by ...