Herbert Irving Comprehensive Cancer Center,
Division of Digestive and Liver Diseases,
Department of Medicine,
Division of Digestive and Liver Diseases, Department of Medicine
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Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium.
Laboratory investigation; a journal of technical methods and pathology Dec, 2009 | Pubmed ID: 19841619
K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia.
Cancer research Nov, 2010 | Pubmed ID: 20959488
Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice.
American journal of cancer research Apr, 2011 | Pubmed ID: 21761008
Bile Acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia.
Cancer cell Jan, 2012 | Pubmed ID: 22264787
Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.
Gastroenterology Feb, 2013 | Pubmed ID: 23085486
Recurrence of Esophageal Intestinal Metaplasia After Endoscopic Mucosal Resection and Radiofrequency Ablation of Barrett's Esophagus: Results From a US Multicenter Consortium.
Gastroenterology Jul, 2013 | Pubmed ID: 23499759
Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research.
Gastroenterology Jun, 2014 | Pubmed ID: 24768332
Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia.
Molecular imaging , 2014 | Pubmed ID: 24824854
Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 25558829
Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
Cell Jan, 2015 | Pubmed ID: 25594183
Radiofrequency Ablation Is Associated With Decreased Neoplastic Progression in Patients With Barrett's Esophagus and Confirmed Low-Grade Dysplasia.
Gastroenterology Sep, 2015 | Pubmed ID: 25917785
Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.
Cell stem cell Jun, 2015 | Pubmed ID: 26046762
Imaging of Secreted Extracellular Periostin, an Important Marker of Invasion in the Tumor Microenvironment in Esophageal Cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Aug, 2015 | Pubmed ID: 26069303
Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2015 | Pubmed ID: 26202952
Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia.
Oncotarget Oct, 2015 | Pubmed ID: 26460825
Our New President-Timothy C. Wang, MD.
Gastroenterology May, 2016 | Pubmed ID: 27018487
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
Cell stem cell Apr, 2016 | Pubmed ID: 27058937
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
Oncotarget Jan, 2017 | Pubmed ID: 27448962
Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.
The Journal of clinical investigation Jun, 2017 | Pubmed ID: 28481227
A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.
Gastroenterology Jul, 2017 | Pubmed ID: 28583825
Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.
Nature communications Nov, 2017 | Pubmed ID: 29170450
Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Feb, 2020 | Pubmed ID: 31077828
Mechanisms Underlying Metastatic Pancreatic Cancer.
Advances in experimental medicine and biology , 2019 | Pubmed ID: 31576536
Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus.
Development (Cambridge, England) Dec, 2019 | Pubmed ID: 31748205
Mutant p53 on the Path to Metastasis.
Trends in cancer Jan, 2020 | Pubmed ID: 31952783
Outcomes of patients with submucosal (T1b) esophageal adenocarcinoma: a multicenter cohort study.
Gastrointestinal endoscopy Jul, 2020 | Pubmed ID: 31953189
Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer.
Genetics in medicine : official journal of the American College of Medical Genetics May, 2020 | Pubmed ID: 32051609
Associations of sociodemographic and clinical factors with gastrointestinal cancer risk assessment appointment completion.
Journal of genetic counseling Aug, 2020 | Pubmed ID: 32227561
Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids.
Current protocols in stem cell biology Jun, 2020 | Pubmed ID: 32294323
Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.
Gastroenterology Aug, 2020 | Pubmed ID: 32325086
Our New President-M. Bishr Omary, MD, PhD, AGAF.
Gastroenterology May, 2020 | Pubmed ID: 32364115
EMT, MET, Plasticity, and Tumor Metastasis.
Trends in cell biology Oct, 2020 | Pubmed ID: 32800658
Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology.
Gastroenterology Jan, 2021 | Pubmed ID: 33007300
2020 American Pancreatic Association Presidential Address: Pancreatology-at the Crossroads.
Pancreas , 2020 | Pubmed ID: 33122512
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
Gastroenterology 03, 2021 | Pubmed ID: 33197448
Growth of pancreatic cancers with hemizygous chromosomal 17p loss of can be preferentially targeted by PARP inhibitors.
Science advances Dec, 2020 | Pubmed ID: 33277249
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.
Genes & development Jan, 2021 | Pubmed ID: 33303641
Potential Molecular Targets in the Setting of Chemoradiation for Esophageal Malignancies.
Journal of the National Cancer Institute Jun, 2021 | Pubmed ID: 33351071
Rab11-FIP1 mediates epithelial-mesenchymal transition and invasion in esophageal cancer.
EMBO reports Feb, 2021 | Pubmed ID: 33403789
A clinical prediction model to assess risk for pancreatic cancer among patients with prediabetes.
European journal of gastroenterology & hepatology Jan, 2022 | Pubmed ID: 33470698
PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability.
Cancer discovery Jul, 2021 | Pubmed ID: 33589425
Mutant p53 regulates Survivin to foster lung metastasis.
Genes & development Apr, 2021 | Pubmed ID: 33737385
LIN28B induces a differentiation program through CDX2 in colon cancer.
JCI insight May, 2021 | Pubmed ID: 33755595
Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review.
Pancreas Mar, 2021 | Pubmed ID: 33835956
Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome.
Gastroenterology Aug, 2021 | Pubmed ID: 33839100
COVID-19 related pancreatic cancer surveillance disruptions amongst high-risk individuals.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Apr, 2021 | Pubmed ID: 33926820
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.
Nature genetics Jun, 2021 | Pubmed ID: 33972779
Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics.
iScience May, 2021 | Pubmed ID: 34027324
Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment.
Trends in cancer Aug, 2021 | Pubmed ID: 34074623
Pancreatic plasticity: Unlocking exocrine lineage specification.
Cell stem cell Jun, 2021 | Pubmed ID: 34087158
Stem cells and origins of cancer in the upper gastrointestinal tract.
Cell stem cell Aug, 2021 | Pubmed ID: 34129814
Threshold Analysis of the Cost-effectiveness of Endoscopic Ultrasound in Patients at High Risk for Pancreatic Ductal Adenocarcinoma.
Pancreas Jul, 2021 | Pubmed ID: 34149034
Multigene Panel Testing in Individuals With Hepatocellular Carcinoma Identifies Pathogenic Germline Variants.
JCO precision oncology , 2021 | Pubmed ID: 34250406
Calcium signaling induces a partial EMT.
EMBO reports Sep, 2021 | Pubmed ID: 34324787
EUS-based Pancreatic Cancer Surveillance in Carriers Without a Family History of Pancreatic Cancer.
Cancer prevention research (Philadelphia, Pa.) Nov, 2021 | Pubmed ID: 34341011
Single-cell analysis of ductal differentiation.
Nature biomedical engineering Aug, 2021 | Pubmed ID: 34389821
Diversity in Leadership at Academic Medical Centers: Addressing Underrepresentation Among Asian American Faculty.
JAMA Aug, 2021 | Pubmed ID: 34402820
Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Letter.
Cancer prevention research (Philadelphia, Pa.) Oct, 2021 | Pubmed ID: 34607877
Patient-derived organoids as a platform for modeling a patient's response to chemoradiotherapy in esophageal cancer.
Scientific reports Oct, 2021 | Pubmed ID: 34716381
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.
Gastroenterology Mar, 2022 | Pubmed ID: 34883119
Presentation of the Julius M. Friedenwald Medal to Timothy C. Wang, MD, AGAF.
Gastroenterology Jun, 2022 | Pubmed ID: 35443933
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Oct, 2022 | Pubmed ID: 35704792
A cellular hierarchy in melanoma uncouples growth and metastasis.
Nature Oct, 2022 | Pubmed ID: 36131018
Author Correction: A cellular hierarchy in melanoma uncouples growth and metastasis.
Nature Nov, 2022 | Pubmed ID: 36261534
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.
Nature communications Nov, 2022 | Pubmed ID: 36329064
Tumor suppressive and immune-stimulating roles of cholesterol 25-hydroxylase in pancreatic cancer cells.
Molecular cancer research : MCR Nov, 2022 | Pubmed ID: 36378658
KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.
Cancer cell Dec, 2022 | Pubmed ID: 36525973
Samuel Flashner*,1,
Cecilia Martin*,1,2,
Norihiro Matsuura1,
Masataka Shimonosono1,
Yasuto Tomita1,
Masaki Morimoto1,
Ogoegbunam Okolo1,
Victoria X. Yu1,3,
Anuraag S. Parikh1,3,
Andres J. P. Klein-Szanto4,
Kelley Yan1,2,
Joel T. Gabre1,5,
Chao Lu1,6,
Fatemeh Momen-Heravi1,7,
Anil K. Rustgi1,5,
Hiroshi Nakagawa1,2,5
1Herbert Irving Comprehensive Cancer Center, Columbia University,
2Organoid and Cell Culture Core, Columbia University Digestive and Liver Diseases Research Center, Columbia University,
3Department of Otolaryngology, Head and Neck Surgery, Columbia University,
4Histopathology Facility, Fox Chase Cancer Center,
5Division of Digestive and Liver Diseases, Department of Medicine, Columbia University,
6Department of Genetics and Development, Columbia University,
7Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University
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