William Kwok

Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis.

HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.

Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones.

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.

Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

HLA class II peptide-binding and autoimmunity.

Defining antigen-specific responses with human MHC class II tetramers.

Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma.

Use of class II tetramers for identification of CD4+ T cells.

Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity.

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells.

Challenges in staining T cells using HLA class II tetramers.

Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.

Low-avidity recognition by CD4+ T cells directed to self-antigens.

P53(110-124)-specific human CD4+ T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8+ T cells.

HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination.

Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2.

Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.

Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.

HLA class II polymorphisms determine responses to bacterial superantigens.

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.

Autoreactive T cells in healthy individuals.

Extensive replicative capacity of human central memory T cells.

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.

In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of BirA enzyme for the generation of MHC class II/tetramers.

Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2.

Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane.

Functional avidity directs T-cell fate in autoreactive CD4+ T cells.

Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells.

Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells.

Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells.

The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.

Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.

Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.

Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.

Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.

Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals.

Multiplex mapping of CD4 T cell epitopes using class II tetramers.

HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.

Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers.

Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers.

CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65.

Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine.

Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy.

Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus.

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.

Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition.

Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis.

Tracking antigen specific CD4+ T-cells with soluble MHC molecules.

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis.

Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.

Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.

Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection.

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope.

Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.

The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells.

Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals.

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.

H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.

The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.

Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.

Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.

Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.

HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.

Direct ex vivo analysis of allergen-specific CD4+ T cells.

HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.

Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses.

Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy.

Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis.

Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.

Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis.

Ara h 1-reactive T cells in individuals with peanut allergy.

Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis.

Autoreactive CD4(+) T cells in patients with atopic dermatitis.

Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.

Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.

Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.

Differentiation stage determines pathologic and protective allergen-specific CD4(+) T-cell outcomes during specific immunotherapy.

Induction and maintenance of allergen-specific FOXP3(+) Treg cells in human tonsils as potential first-line organs of oral tolerance.

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.

DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9.

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence.

Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire.