Accessing Early Differentiation of Virus-Specific Follicular Helper CD4⁺ T Cell in Acute LCMV-Infected Mice

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05:03 min

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April 26th, 2024

DOI :

10.3791/66752-v

April 26th, 2024

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Yao Lin*¹^,², Shuai Yue*³, Yang Yang*⁴, Junjian He⁵, Xiaofan Yang⁶, Lilin Ye⁵, Xiangyu Chen⁷

¹Department of Urology, South China Hospital, Medical School, Shenzhen University, ²Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, ³Cancer Center, Daping Hospital & Army Medical Center of PLA, Third Military Medical University, ⁴Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, ⁵Institute of Immunology, Third Military Medical University, ⁶Dermatology Hospital, Southern Medical University, ⁷Institute of Immunological Innovation and Translation, Chongqing Medical University

Transcript

Summary

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Follicular Helper T Cells

CD4 T Cells

Virus specific TFH Cells

LCMV Infection

Acute Lymphocytic Choriomeningitis Virus

Flow Cytometry Staining

In vivo Stimulation

Retroviral vector based Gene Manipulation

T cell dependent Humoral Immunity

Vaccine Design

Early Fate Commitment

Gene Expression Manipulation

Chapters in this video

0:00

Introduction

1:01

Mapping the Early Development of LCMV‐Specific Follicular Helper T‐Cells in Mice

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Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4⁺ T Cell in Acute LCMV-Infected Mice