Anesthetizing and Preparing the Animal for Surgery
2:24
Stereotaxic Surgery
6:31
Apomorphine Induced Rotation Test
7:27
Conclusion
Parkinson disease is caused by loss of dopaminergic innervation to the striatum, which can be experimentally induced by 6-OH-dopamine. We describe how to perform a stereotaxic lesion and to monitor apomorphine-induced rotational behavior in mice. This model is useful and reliable for testing new therapies for Parkinson disease.