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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)

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10:05 min

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January 20th, 2016

DOI :

10.3791/53510-v

January 20th, 2016

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8,074 Views

Graham S. Erwin¹, Matthew P. Grieshop¹, Devesh Bhimsaria^1,2, Asuka Eguchi³, José A. Rodríguez-Martínez¹, Aseem Z. Ansari^1,4

¹Department of Biochemistry, University of Wisconsin–Madison, ²Department of Electrical and Computer Engineering, University of Wisconsin–Madison, ³Graduate Program in Cellular and Molecular Biology, University of Wisconsin–Madison, ⁴The Genome Center, University of Wisconsin–Madison

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Keywords Genome wide Mapping

Drug DNA Interactions

Small Molecules

Mechanism Of Action

Therapeutic Agents

DNA targeting Molecules

Pluripotent Stem Cells

Photo cross linking

Cell Dissociation

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